Severe clinical presentation of visceral leishmaniasis in naturally infected dogs with disruption of the splenic white pulp
| Autor: | Floriano G Leal Junior, Joselli Santos Silva, Washington Luis Conrado dosSantos, Luiz Antonio Rodrigues de Freitas, Isadora dos Santos Lima, José P Moura-Neto, Daniela Farias Larangeira, Patrício An Souza, Valter dos Anjos Almeida, Deborah Bittencourt Mothé Fraga |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology lcsh:Medicine Protozoology chemistry.chemical_compound Dog Diseases Leishmania infantum lcsh:Science Leishmaniasis Leishmania Multidisciplinary biology Zoonotic Diseases medicine.anatomical_structure Lymphatic system Infectious Diseases Veterinary Diseases Medicine Leishmaniasis Visceral Female Veterinary Pathology Research Article Neglected Tropical Diseases Veterinary Medicine medicine.medical_specialty Anemia Immunology Spleen Enzyme-Linked Immunosorbent Assay Immunopathology Real-Time Polymerase Chain Reaction Microbiology Veterinary Immunology Dogs medicine Parasitic Diseases Animals Biology Creatinine business.industry lcsh:R Albumin DNA Protozoan biology.organism_classification medicine.disease Veterinary Parasitology Visceral leishmaniasis chemistry Parastic Protozoans Veterinary Science lcsh:Q business Biomarkers |
| Zdroj: | PLoS ONE, Vol 9, Iss 2, p e87742 (2014) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | In this work, we investigated the association between the disruption of splenic lymphoid tissue and the severity of visceral leishmaniasis in dogs. Clinical and laboratory data from 206 dogs were reviewed. Spleen sections collected during the euthanasia of these animals were analyzed, and the splenic lymphoid tissue samples were classified as well organized (spleen type 1), slightly disorganized (spleen type 2), or moderately to extensively disorganized (spleen type 3). Of 199 dogs with evidence of Leishmania infection, 54 (27%) had spleen type 1, 99 (50%) had spleen type 2, and 46 (23%) had spleen type 3. The number of clinical signs associated with visceral leishmaniasis was significantly higher in the animals with evidence of Leishmania infection and spleen type 2 or 3 than in the animals with spleen type 1. Alopecia, anemia, dehydration, dermatitis, lymphadenopathy, and onychogryphosis were all more frequent among animals with evidence of Leishmania infection and spleen type 3 than among the dogs with evidence of Leishmania infection and spleen type 1. The association between the severity of canine visceral leishmaniasis and the disorganization of the splenic lymphoid tissue was even more evident in the group of animals with positive spleen culture. Conjunctivitis and ulceration were also more common in the animals with spleen type 3 than in the animals with spleen type 1. The serum levels (median, interquartile range) of albumin (1.8, 1.4–2.3 g/dL) and creatinine (0.7, 0.4–0.8 mg/dL) were significantly lower and the serum levels of aspartate aminotransferase were significantly higher (57, 39–95 U) in animals with spleen type 3 than in animals with spleen type 1 (2.8, 2.4–3.4 g/dL; 0.9, 0.7–1.2 mg/dL and 23, 20–32 U, respectively). Our data confirm the hypothesis that disruption of the splenic lymphoid tissue is associated with a more severe clinical presentation of canine visceral leishmaniasis. |
| Databáze: | OpenAIRE |
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