Influenza A and the virus associated haemophagocytic syndrome: cluster of three cases in children with acute leukaemia
| Autor: | M. N. Potter, Anthony Oakhill, A. B. M. Foot |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Histiocytosis Non-Langerhans-Cell Congenital cytomegalovirus infection medicine.disease_cause Virus Pathology and Forensic Medicine Sepsis Influenza Human Influenza A virus Humans Medicine Child business.industry virus diseases General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Pancytopenia Virology Leukemia Myeloid Acute Leukemia medicine.anatomical_structure Child Preschool Immunology Female Viral disease Bone marrow business Research Article |
| Zdroj: | Journal of Clinical Pathology. 44:297-299 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.44.4.297 |
| Popis: | At the height of the United Kingdom influenza A epidemic in December 1989, three children receiving treatment for non-T cell acute leukaemia developed pancytopenia with concomitant influenza A infection. Bone marrow histology showed prominent marrow erythrophagocytosis by morphologically mature histiocytes, consistent with the picture of virus associated haemophagocytic syndrome (VAHS). In two cases there was an initial spontaneous recovery, though recurrence of VAHS developed in one case in association with a different viral infection (cytomegalovirus) following autologous bone marrow transplantation. The third child died from cardiorespiratory failure secondary to infection with influenza A and Klebsiella pneumoniae sepsis. It is suggested that influenza A should be added to the list of infective causative agents. |
| Databáze: | OpenAIRE |
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