Monocyte chemotactic protein-1 and CC chemokine receptor 2 polymorphisms and prognosis of renal cell carcinoma
| Autor: | Guan-Xian Liu, Su Li, Hai-Han Song, Richard D. Koiiche, Xin Zhang, Jerry H. Sindsceii |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty CCR2 Receptors CCR2 Kaplan-Meier Estimate Biology Malignancy Gastroenterology Polymorphism Single Nucleotide Gene Frequency Renal cell carcinoma Internal medicine Genotype medicine Humans Genetic Predisposition to Disease Receptor Survival rate Carcinoma Renal Cell Chemokine CCL2 Genetic Association Studies Aged Monocyte General Medicine Middle Aged medicine.disease Prognosis Kidney Neoplasms medicine.anatomical_structure Amino Acid Substitution Case-Control Studies Immunology Female CC chemokine receptors |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 34(5) |
| ISSN: | 1423-0380 |
| Popis: | Monocyte chemoattractant protein-1 (MCP-1) and its receptor CC chemokine receptor 2 (CCR2) play a major role in inflammation and proliferation of cancers. We investigated a possible association between polymorphisms in MCP-1 and CCR2 genes (MCP-1 -2518A/G and CCR2 190G/A or V64I) and the risk as well as prognosis of renal cell carcinoma (RCC). Genotypes were determined by polymerase chain reaction–restriction fragment length polymorphism in 416 RCC cases and 458 age-matched healthy controls. Frequency of MCP-1 2518GG genotype for cases and controls was 0.384 and 0.286, respectively; individuals carrying the GG genotype had a 1.89-fold increased risk of RCC than those with AA genotype (95 % confidence interval [CI] 1.24–2.81, p = 0.002; data were adjusted for age and sex). Frequency of CCR2 190AA (64I/64I) genotype for cases and controls was 0.175 and 0.076, respectively; subjects having AA genotype had a 2.68-fold increased risk of RCC compared to those with the wild-type GG genotype (95 %CI 1.71–4.17, p = 4.3 × 10−6; data were adjusted for age and sex). When analyzing the survival rate of RCC, patients with MCP-1 -2518GG genotype revealed significantly shorter survival time compared to cases with MCP-1 -2518AA and AG genotypes (p = 0.003). Similarly, RCC cases carrying CCR2 190AA genotype showed significantly shorter survival rate than patients with GG or GA genotypes (p |
| Databáze: | OpenAIRE |
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