Effects of antidepressant drug imipramine on gene expression in rat prefrontal cortex
| Autor: | Eero Castrén, Juha E.A. Knuuttila, Petri Törönen |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Proteases Imipramine Microarray Prefrontal Cortex Nerve Tissue Proteins Pharmacology Antidepressive Agents Tricyclic Biochemistry Serine 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Gene expression medicine Cyclic AMP Animals Rats Wistar Gene 030304 developmental biology Serine protease 0303 health sciences biology Serine Endopeptidases General Medicine Oncogenes Rats biology.protein Antidepressant 030217 neurology & neurosurgery Algorithms medicine.drug |
| Zdroj: | University of Helsinki |
| ISSN: | 0364-3190 |
| Popis: | We have investigated gene expression changes produced by acute and chronic daily treatment with a prototypical antidepressant, imipramine, using DNA microarrays. The analysis of similarities in gene expression patterns among functionally related genes revealed four expression profile cluster areas that showed a highly significant overrepresentation of several functional classes. Genes encoding for proteins involved in cAMP metabolism, postsynaptic membrane proteins, and proto-oncogenes were overrepresented in different cluster areas. Furthermore, we found that serine proteases as a group were similarly regulated by chronic antidepressant treatment. Our data suggest that cAMP metabolism, synaptic function, and protein processing by serine proteases may be important targets of antidepressant treatment and potential objects for antidepressant drug development. |
| Databáze: | OpenAIRE |
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