Systemic circulating inflammatory burden and periodontitis in adolescents
| Autor: | Gustavo G. Nascimento, Bruno Braga Benatti, Cadidja Dayane Sousa do Carmo, Ana Regina Oliveira Moreira, Renato V C Casarin, Cecília Cláudia Costa Ribeiro, Cláudia Maria Coelho Alves |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Mediation (statistics)
medicine.medical_specialty Adolescent Bleeding on probing Population Disease Gastroenterology 03 medical and health sciences Gingivitis 0302 clinical medicine Internal medicine medicine education Periodontitis General Dentistry Adiposity education.field_of_study business.industry Smoking Inflammation mediators 030206 dentistry medicine.disease Blood pressure Clinical attachment loss 030220 oncology & carcinogenesis medicine.symptom business |
| Zdroj: | Ribeiro, C C C, Carmo, C D S, Benatti, B B, Casarin, R V C, Alves, C M C, Nascimento, G G & Moreira, A R O 2021, ' Systemic circulating inflammatory burden and periodontitis in adolescents ', Clinical Oral Investigations, vol. 25, no. 10, pp. 5855-5865 . https://doi.org/10.1007/s00784-021-03891-y |
| DOI: | 10.1007/s00784-021-03891-y |
| Popis: | Objectives: To analyze the association between systemic inflammatory burden of cardiovascular disease (CVD) risk and periodontitis in adolescents, including mediating pathways triggered by their common risk factors. Materials and methods: Using a population-based sample study (n = 405) of Brazilian adolescents (17–18 years old), direct and mediation pathways triggered by “Socioeconomic Status,” “Adiposity,” Smoking, and “Blood Pressure” were modelled for the association between the “Systemic Circulating Inflammatory Burden of CVD Risk” (IL-1β, IL-6, IL-8, TNF-α) and the “Initial Periodontitis” (bleeding on probing (BoP), probing depth (PD) ≥ 4 mm, clinical attachment loss (CAL) ≥ 4 mm), both as continuous latent variables, using structural equation modeling. Sensitivity analysis was performed for the outcomes “Gingivitis” (visible plaque; BoP); “Moderate Periodontitis” (PD ≥ 5 mm and CAL ≥ 5 mm) and periodontitis (CDC-AAP case definition). Results: Higher “Systemic Circulating Inflammatory Burden of CVD Risk” was directly associated with higher “Initial Periodontitis” (standardized coefficient [SC] = 0.178, P value < 0.001). Lower “Socioeconomic Status” (SC = − 0.022, P value = 0.015) and Smoking (SC = 0.030, P value = 0.021) triggered the “Initial Periodontitis”, mediated by “Systemic Circulating Inflammatory Burden of CVD Risk”. Sensitivity analysis showed a dose-response relationship between “Systemic Circulating Inflammatory Burden of CVD Risk” and “Moderate Periodontitis” (SC = 0.323, P value = 0.021). Conclusions: “Systemic Circulating Inflammatory Burden of CVD Risk” appeared as an underlying mechanism of early periodontal breakdown in adolescents, also triggered by social vulnerability and smoking. Clinical relevance: The association between periodontitis and CVD in adulthood seems to establish much earlier in life than had been previously studied, giving impetus to preventive approaches focused on their common risk factors. |
| Databáze: | OpenAIRE |
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