Three-dimensional conformal postoperative radiotherapy in patients with parotid tumors: 10 years' experience at the European Institute of Oncology
| Autor: | Daniela, Alterio, Barbara A, Jereczek-Fossa, Mara, Griseri, Alberto, D'Onofrio, Gioacchino, Giugliano, Maria R, Fiore, Viviana, Vitolo, Piero, Fossati, Gaia, Piperno, Luca S, Calabrese, Elena, Verri, Fausto G, Chiesa, Roberto, Orecchia |
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| Přispěvatelé: | Alterio, D, Jereczek-Fossa, Ba, Griseri, M, D'Onofrio, A, Giugliano, G, Fiore, Mr, Vitolo, V, Fossati, P, Piperno, G, Calabrese, L, Verri, E, Chiesa, Fg, Orecchia, R |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Cancer Research Time Factors Oncology Radiotherapy Biostatistics Cystadenocarcinoma Adenocarcinoma Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Carcinosarcoma Humans 030223 otorhinolaryngology Aged Neoplasm Staging Retrospective Studies Aged 80 and over Mouth Mucosa Dose-Response Relationship Radiation General Medicine Middle Aged Parotid Neoplasms Europe Treatment Outcome 030220 oncology & carcinogenesis Carcinoma Squamous Cell Feasibility Studies Carcinoma Mucoepidermoid Female Dose Fractionation Radiation Neoplasm Recurrence Local Radiotherapy Conformal |
| Popis: | Aims and background Salivary gland malignancies are rare. The aim of our study was to investigate radiotherapy-related toxicity and clinical outcome in patients treated at our division with postoperative radiotherapy (pRT) for parotid tumors. Methods and study design Forty-three consecutive patients (32 with primary parotid tumors, 9 with parotid metastases and 2 with recurrent benign diseases) were retrospectively analyzed. Results The median follow-up was 28 months. Twenty and 5 patients had a follow-up longer than 2 and 5 years, respectively. Thirty-seven patients were alive and most of them (78%) were free from disease. The local and distant control rates were higher in patients with primary parotid tumors (94% and 87.5%) than in patients with parotid metastases (87.5% and 75%). Grade 3 radiotherapy-related acute toxicity of skin and mucosa was recorded in 20.9% and 28% of patients, respectively. Two patients (4.7%) had grade 4 skin toxicity. Late toxicity data were available for 33 (77%) patients. None of the patients developed severe (grade 3 and 4) late toxicity of soft tissues, skin or temporomandibular joints. Conclusions Postoperative radiotherapy is a feasible treatment that was found to be effective mainly in patients with primary parotid tumors. Toxicity was acceptable but could probably be further reduced using more advanced radiotherapy techniques. Longer follow-up is required to achieve definitive results. |
| Databáze: | OpenAIRE |
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