Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice
| Autor: | Raquel Hontecillas, Louis M. Havekes, Peter J. Voshol, Irene O.C.M. Vroegrijk, Luisa Gambelli, Gerben Zondag, Janna A. van Diepen, Sjoerd A.A. van den Berg, Johannes A. Romijn, Josep Bassaganya-Riera, Hiskias G. Keizer, Irene Westbroek |
|---|---|
| Přispěvatelé: | General Internal Medicine |
| Rok vydání: | 2011 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Linolenic Acids 030309 nutrition & dietetics medicine.medical_treatment Biology Toxicology Eating Mice 03 medical and health sciences chemistry.chemical_compound Metabolic flexibility Insulin resistance Internal medicine medicine Animals Insulin Plant Oils Obesity 030304 developmental biology Lythraceae 2. Zero hunger 0303 health sciences Punicic acid Glucose tolerance test medicine.diagnostic_test Health aging / healthy living Pathogenesis and modulation of inflammation [IGMD 5] General Medicine Metabolism Glucose Tolerance Test Glucose clamp technique medicine.disease Dietary Fats Mice Inbred C57BL Disease Models Animal Vegetable oil Endocrinology chemistry Seeds Glucose Clamp Technique Energy expenditure Food Science |
| Zdroj: | Food and Chemical Toxicology, 49, 1426-30 Food and Chemical Toxicology, 49, 6, pp. 1426-30 Food and chemical toxicology, 49(6), 1426-1430. Elsevier Limited Food and Chemical Toxicology; Vol 49 Food and Chemical Toxicology |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2011.03.037 |
| Popis: | Item does not contain fulltext BACKGROUND: Pomegranate seed oil has been shown to protect against diet induced obesity and insulin resistance. OBJECTIVE: To characterize the metabolic effects of punicic acid on high fat diet induced obesity and insulin resistance. DESIGN: High-fat diet or high-fat diet with 1% Pomegranate seed oil (PUA) was fed for 12 weeks to induce obesity and insulin resistance. We assessed body weight and composition (pSABRE DEXA-scan), energy expenditure (Columbus Instruments) and insulin sensitivity at the end of the 12 weeks. RESULTS: PSO intake resulted in a lower body weight, 30.5+/-2.9 vs 33.8+/-3.2 g PSO vs HFD respectively, p=0.02, without affecting food intake or energy expenditure. The lower body weight was fully explained by a decreased body fat mass, 3.3+/-2.3 vs 6.7+/-2.7 g for PSO and HFD fed mice, respectively, p=0.02. Insulin clamps showed that PSO did not affect liver insulin sensitivity but clearly improved peripheral insulin sensitivity, 164+/-52% vs 92+/-24% for PSO and HFD fed mice respectively, p=0.01. CONCLUSIONS: We conclude that dietary PSO ameliorates high-fat diet induced obesity and insulin resistance in mice, independent of changes in food intake or energy expenditure. 01 juni 2011 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect