Characterization of Zero-Valent Iron Nanoparticles Functionalized with a Biomarker Peptide
| Autor: | Yehidi Julieth Medina Castillo, Javier Rincón, Daniel Llamosa Pérez, Monica Losada-Barragán, Carlos Arturo Parra Vargas, Karina Vargas Sanchez, Indry Milena Saavedra Gaona |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Zero-valent iron Nanoparticle Nanotechnology Peptide medicine General Materials Science Fourier transform infrared spectroscopy Materials of engineering and construction. Mechanics of materials chemistry.chemical_classification Zerovalent iron medicine.diagnostic_test Mechanical Engineering Magnetic resonance imaging equipment and supplies Condensed Matter Physics peptide Biomarker (cell) Characterization (materials science) chemistry Mechanics of Materials magnetic composite nanoparticles TA401-492 Magnetic nanoparticles human activities MRI |
| Zdroj: | Materials Research, Vol 24, Iss 5 (2021) Materials Research, Volume: 24, Issue: 5, Article number: e20200599, Published: 03 SEP 2021 Materials Research v.24 n.5 2021 Materials research (São Carlos. Online) Universidade Federal de São Carlos (UFSCAR) instacron:ABM ABC ABPOL |
| ISSN: | 1980-5373 1516-1439 |
| Popis: | The identification of peptides that can be coupled to magnetic nanoparticles and be directed against specific receptors has been developed and applied intensively in various biomedical applications, such as magnetic resonance imaging (MRI), to diagnose neurodegenerative diseases. This work describes the properties of magnetic zero-valent iron (nZVI) nanoparticles coated with silica and subsequently decorated with a peptide as a biomarker of neuroinflammation. The synthesized nanostructured compounds were systematically characterized by XRD, SEM, AFM, DLS, FTIR and VSM techniques. Biotin-Streptavin-HRP system was carried out to confirm the peptide's anchoring to the surface of the nanoparticles. The results showed that this nanostructured compound is an excellent candidate as a contrast agent capable of being used in magnetic resonance imaging, which would optimize the diagnosis of neuroinflammatory lesions compared to current contrast media. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|