The microbiome of dental and peri-implant subgingival plaque during peri-implant mucositis therapy
| Autor: | Bernd W. Brandt, Mark J. Buijs, Juliana Philip, Egija Zaura, Vincent Y. Pappalardo, Wim Crielaard |
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| Přispěvatelé: | Human Genetics, Graduate School, Oral Implantology, Preventive Dentistry |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Mucositis
Peri-implant mucositis medicine.medical_treatment Dental Plaque Dentistry microbiome subgingival plaque Gingivitis medicine Humans delmopinol Microbiome Dental implant Dental Implants dental implant business.industry Microbiota Chlorhexidine chlorhexidine medicine.disease peri-implant mucositis submucosal plaque Peri-Implantitis Debridement (dental) Periodontics Implant medicine.symptom business medicine.drug |
| Zdroj: | Journal of clinical periodontology, 49(1), 28-38. Blackwell Munksgaard Journal of Clinical Periodontology, 49(1), 28-38. Blackwell Munksgaard Philip, J, Buijs, M J, Pappalardo, V Y, Crielaard, W, Brandt, B W & Zaura, E 2022, ' The microbiome of dental and peri-implant subgingival plaque during peri-implant mucositis therapy : A randomized clinical trial ', Journal of Clinical Periodontology, vol. 49, no. 1, pp. 28-38 . https://doi.org/10.1111/jcpe.13566 |
| ISSN: | 0303-6979 |
| Popis: | Aim: To assess the microbial effects of mechanical debridement in conjunction with a mouthrinse on sites with peri-implant mucositis and gingivitis. Materials and methods: Eighty-nine patients with peri-implant mucositis were included in a double-blinded, randomized, placebo-controlled trial with mechanical debridement and 1-month use of either delmopinol, chlorhexidine (CHX), or a placebo mouthrinse. Submucosal and subgingival plaque samples of implants and teeth were collected at baseline and after 1 and 3 months, processed for 16S V4 rRNA gene amplicon sequencing, and analysed bioinformatically. Results: The sites with peri-implant mucositis presented with a less diverse and less anaerobic microbiome. Exposure to delmopinol or CHX, but not to the placebo mouthrinse resulted in microbial changes after 1 month. The healthy sites around the teeth harboured a more diverse and more anaerobe-rich microbiome than the healthy sites around the implants. Conclusions: Peri-implant sites with mucositis harbour ecologically less complex and less anaerobic biofilms with lower biomass than patient-matched dental sites with gingivitis while eliciting an equal inflammatory response. Adjunctive antimicrobial therapy in addition to mechanical debridement does affect both dental and peri-implant biofilm composition in the short term, resulting in a less dysbiotic subgingival biofilm. |
| Databáze: | OpenAIRE |
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