Changes in immune parameters seen in Gulf War veterans but not in civilians with chronic fatigue syndrome
| Autor: | Thomas N. Denny, Marc H. Lavietes, Claudia Pollet, John E. Ottenweller, William C. Gause, Gudrun Lange, John J. LaManca, Xia-Di Zhou, Benjamin H. Natelson, Quanwu Zhang |
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| Rok vydání: | 1999 |
| Předmět: |
Microbiology (medical)
Interleukin 2 Adult Male Clinical Biochemistry Immunology Population Gene Expression Major histocompatibility complex Models Biological Article Immune system Antigen Antigens CD T-Lymphocyte Subsets medicine Chronic fatigue syndrome Immunology and Allergy Humans Persian Gulf Syndrome RNA Messenger education education.field_of_study Fatigue Syndrome Chronic biology business.industry Case-control study Middle Aged medicine.disease humanities Lymphocyte Subsets Killer Cells Natural Case-Control Studies biology.protein Cytokines Tumor necrosis factor alpha Female business medicine.drug |
| Zdroj: | Clinical and diagnostic laboratory immunology. 6(1) |
| ISSN: | 1071-412X |
| Popis: | The purpose of this study was to evaluate immune function through the assessment of lymphocyte subpopulations (total T cells, major histocompatibility complex [MHC] I- and II-restricted T cells, B cells, NK cells, MHC II-restricted T-cell-derived naive and memory cells, and several MHC I-restricted T-cell activation markers) and the measurement of cytokine gene expression (interleukin 2 [IL-2], IL-4, IL-6, IL-10, IL-12, gamma interferon [IFN-γ], and tumor necrosis factor alpha [TNF-α]) from peripheral blood lymphocytes. Subjects included two groups of patients meeting published case definitions for chronic fatigue syndrome (CFS)—a group of veterans who developed their illness following their return home from participating in the Gulf War and a group of nonveterans who developed the illness sporadically. Case control comparison groups were comprised of healthy Gulf War veterans and nonveterans, respectively. We found no significant difference for any of the immune variables in the nonveteran population. In contrast, veterans with CFS had significantly more total T cells and MHC II + T cells and a significantly higher percentage of these lymphocyte subpopulations, as well as a significantly lower percentage of NK cells, than the respective controls. In addition, veterans with CFS had significantly higher levels of IL-2, IL-10, IFN-γ, and TNF-α than the controls. These data do not support the hypothesis of immune dysfunction in the genesis of CFS for sporadic cases of CFS but do suggest that service in the Persian Gulf is associated with an altered immune status in veterans who returned with severe fatiguing illness. |
| Databáze: | OpenAIRE |
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