Effect of Peruvosid (CD412) on excitability and functional refractory period of atrial and ventricular tissues in cardiomyopathy caused by Trypanosoma cruzi
| Autor: | Alberto Drayer, Frederico Moleiro, José Angel Suárez, Alfonso Anselmi, Régulo Suárez |
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| Rok vydání: | 1970 |
| Předmět: |
Chagas disease
medicine.medical_specialty Myocarditis Refractory period Cardiomyopathy Cardiac Glycosides Electrocardiography Dogs Internal medicine parasitic diseases Animals Medicine Chagas Disease cardiovascular diseases skin and connective tissue diseases Trypanosoma cruzi biology medicine.diagnostic_test business.industry Myocardium Arrhythmias Cardiac Heart Articles medicine.disease biology.organism_classification Endocrinology cardiovascular system Cardiology sense organs Cardiology and Cardiovascular Medicine business |
| Zdroj: | Heart. 32:189-194 |
| ISSN: | 1355-6037 |
| Popis: | Attempts were made to produce myocarditis by Trypanosoma cruzi inoculation in healthy dog puppies 6 to 8 weeks old. Significant electrocardiographic abnormalities were produced, coinciding with interstitial inflammatory processes in the cardiac tissue and with degenerative changes in the myocardial fibres. In puppies showing these changes, profound changes in the excitability and the functional refractory period of the atrial and ventricular muscular tissue were observed. The administration of Peruvosid in doses of 0·0240 to 0·0647 mg./kg. tended to diminish the excitability, previously increased by the inflammatory process, at the same time increasing the functional refractory period duration which had previously been shortened. The fact that Peruvosid corrects these fundamental factors in the genesis of cardiac arrhythmias suggests that the drug may be useful in the treatment of cardiac insufficiency produced by Chagas9 myocardiopathy, in which arrhythmias are one of the basic characteristics. |
| Databáze: | OpenAIRE |
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