An Aminocatalyzed Michael Addition/Iron-Mediated Decarboxylative Cyclization Sequence for the Preparation of 2,3,4,6-Tetrasubstituted Pyridines: Scope and Mechanistic Insights

Autor:	Camila Sartori, Naylil M. R. Capreti, Marcelo Duarte, Igor D. Jurberg, Mateus L. Stivanin, Célio F. F. Angolini
Rok vydání:	2017
Předmět:	010405 organic chemistry Chemistry Stereochemistry Organic Chemistry Michael reaction Sequence (biology) 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences
Zdroj:	The Journal of organic chemistry. 82(19)
ISSN:	1520-6904
Popis:	A novel, scalable strategy for the preparation of 2,3,4,6-tetrasubstituted pyridines is described. This protocol has two steps: an aminocatalyzed addition of ketones to alkylidene isoxazol-5-ones, followed by an iron-mediated decarboxylative cyclization event. Mechanistic insights for both steps are provided based on HRMS-ESI(+) studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75af0d838e81d90e2d07f4a63caab5aa https://pubmed.ncbi.nlm.nih.gov/28905627 Zobrazit plný text záznamu