A mathematical model of the process of ligament repair: Effect of cold therapy and mechanical stress
| Autor: | Rosy Paola Cárdenas Sandoval, Diego Alexander Garzón-Alvarado, Angélica María Ramírez Martínez |
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| Rok vydání: | 2012 |
| Předmět: |
Statistics and Probability
medicine.medical_treatment Inflammation Models Biological General Biochemistry Genetics and Molecular Biology Ligament repair medicine Humans Process (anatomy) Wound Healing General Immunology and Microbiology biology Chemistry Applied Mathematics Growth factor General Medicine Anatomy medicine.anatomical_structure Cryotherapy Modeling and Simulation Ligaments Articular Sprains and Strains Ligament biology.protein Collagen Stress Mechanical Swelling medicine.symptom General Agricultural and Biological Sciences Wound healing Platelet-derived growth factor receptor Biomedical engineering |
| Zdroj: | Journal of Theoretical Biology. 302:53-61 |
| ISSN: | 0022-5193 |
| Popis: | This article proposes a mathematical model that predicts the wound healing process of the ligament after a sprain, grade II. The model describes the swelling, expression of the platelet-derived growth factor (PDGF), formation and migration of fibroblasts into the injury area and the expression of collagen fibers. Additionally, the model can predict the effect of ice treatment in reducing inflammation and the action of mechanical stress in the process of remodeling of collagen fibers. The results obtained from computer simulation show a high concordance with the clinical data previously reported by other authors. |
| Databáze: | OpenAIRE |
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