A New Equation to Estimate Muscle Mass from Creatinine and Cystatin C

Autor: Ho Jun Chin, Sun Wook Kim, Hee-Won Jung, Kwang-Il Kim, Hajeong Lee, Cheol Ho Kim
Rok vydání: 2016
Předmět:
Male
Sarcopenia
Pathology
Muscle Physiology
Muscle Functions
Physiology
lcsh:Medicine
030204 cardiovascular system & hematology
Biochemistry
Diagnostic Radiology
Fats
chemistry.chemical_compound
Absorptiometry
Photon
0302 clinical medicine
Serum cystatin
Medicine and Health Sciences
Medicine
030212 general & internal medicine
lcsh:Science
Musculoskeletal System
Aged
80 and over
Multidisciplinary
biology
Muscles
Radiology and Imaging
Muscle Analysis
Middle Aged
Lipids
Magnetic Resonance Imaging
Bioassays and Physiological Analysis
Adipose Tissue
Connective Tissue
Creatinine
Female
Anatomy
Research Article
Glomerular Filtration Rate
Adult
medicine.medical_specialty
Imaging Techniques
Urology
Renal function
Research and Analysis Methods
Muscle mass
Models
Biological
03 medical and health sciences
Diagnostic Medicine
Humans
Derivation
Absorptiometry
Cystatin C
Bone
Muscle
Skeletal
Aged
Retrospective Studies
business.industry
lcsh:R
Biology and Life Sciences
medicine.disease
Biological Tissue
Cross-Sectional Studies
Skeletal Muscles
chemistry
biology.protein
lcsh:Q
business
Biomarkers
Blood sampling
Zdroj: PLOS ONE(11): 2
PLoS ONE, Vol 11, Iss 2, p e0148495 (2016)
PLoS ONE
ISSN: 1932-6203
Popis: Background With evaluation for physical performance, measuring muscle mass is an important step in detecting sarcopenia. However, there are no methods to estimate muscle mass from blood sampling. Methods To develop a new equation to estimate total-body muscle mass with serum creatinine and cystatin C level, we designed a cross-sectional study with separate derivation and validation cohorts. Total body muscle mass and fat mass were measured using dual-energy x-ray absorptiometry (DXA) in 214 adults aged 25 to 84 years who underwent physical checkups from 2010 to 2013 in a single tertiary hospital. Serum creatinine and cystatin C levels were also examined. Results Serum creatinine was correlated with muscle mass (P < .001), and serum cystatin C was correlated with body fat mass (P < .001) after adjusting glomerular filtration rate (GFR). After eliminating GFR, an equation to estimate total-body muscle mass was generated and coefficients were calculated in the derivation cohort. There was an agreement between muscle mass calculated by the novel equation and measured by DXA in both the derivation and validation cohort (P < .001, adjusted R-2 = 0.829, beta = 0.95, P < .001, adjusted R-2 = 0.856, beta = 1.03, respectively). Conclusion The new equation based on serum creatinine and cystatin C levels can be used to estimate total-body muscle mass.
Databáze: OpenAIRE
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