A New Equation to Estimate Muscle Mass from Creatinine and Cystatin C
Autor: | Ho Jun Chin, Sun Wook Kim, Hee-Won Jung, Kwang-Il Kim, Hajeong Lee, Cheol Ho Kim |
---|---|
Rok vydání: | 2016 |
Předmět: |
Male
Sarcopenia Pathology Muscle Physiology Muscle Functions Physiology lcsh:Medicine 030204 cardiovascular system & hematology Biochemistry Diagnostic Radiology Fats chemistry.chemical_compound Absorptiometry Photon 0302 clinical medicine Serum cystatin Medicine and Health Sciences Medicine 030212 general & internal medicine lcsh:Science Musculoskeletal System Aged 80 and over Multidisciplinary biology Muscles Radiology and Imaging Muscle Analysis Middle Aged Lipids Magnetic Resonance Imaging Bioassays and Physiological Analysis Adipose Tissue Connective Tissue Creatinine Female Anatomy Research Article Glomerular Filtration Rate Adult medicine.medical_specialty Imaging Techniques Urology Renal function Research and Analysis Methods Muscle mass Models Biological 03 medical and health sciences Diagnostic Medicine Humans Derivation Absorptiometry Cystatin C Bone Muscle Skeletal Aged Retrospective Studies business.industry lcsh:R Biology and Life Sciences medicine.disease Biological Tissue Cross-Sectional Studies Skeletal Muscles chemistry biology.protein lcsh:Q business Biomarkers Blood sampling |
Zdroj: | PLOS ONE(11): 2 PLoS ONE, Vol 11, Iss 2, p e0148495 (2016) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | Background With evaluation for physical performance, measuring muscle mass is an important step in detecting sarcopenia. However, there are no methods to estimate muscle mass from blood sampling. Methods To develop a new equation to estimate total-body muscle mass with serum creatinine and cystatin C level, we designed a cross-sectional study with separate derivation and validation cohorts. Total body muscle mass and fat mass were measured using dual-energy x-ray absorptiometry (DXA) in 214 adults aged 25 to 84 years who underwent physical checkups from 2010 to 2013 in a single tertiary hospital. Serum creatinine and cystatin C levels were also examined. Results Serum creatinine was correlated with muscle mass (P < .001), and serum cystatin C was correlated with body fat mass (P < .001) after adjusting glomerular filtration rate (GFR). After eliminating GFR, an equation to estimate total-body muscle mass was generated and coefficients were calculated in the derivation cohort. There was an agreement between muscle mass calculated by the novel equation and measured by DXA in both the derivation and validation cohort (P < .001, adjusted R-2 = 0.829, beta = 0.95, P < .001, adjusted R-2 = 0.856, beta = 1.03, respectively). Conclusion The new equation based on serum creatinine and cystatin C levels can be used to estimate total-body muscle mass. |
Databáze: | OpenAIRE |
Externí odkaz: |