Identification of Risk Factors for Daptomycin-Associated Creatine Phosphokinase Elevation and Development of a Risk Prediction Model for Incidence Probability

Autor:	Junki Inoue, Koji Tanikawa, Masaki Uchida, Ryuji Higashita, Yuki Enoki, Keisuke Takada, Junichi Ishii, Fumio Nagumo, Kazuaki Taguchi, Sakura Koshioka, Naoki Hirose, Masaru Samura, Norifumi Kunika, Takenori Kurata, Kazuaki Matsumoto
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	medicine.medical_specialty biology business.industry Incidence (epidemiology) daptomycin fungi Elevation risk score Major Articles Infectious Diseases AcademicSubjects/MED00290 Oncology risk factor trough concentration Internal medicine biology.protein Cardiology Medicine creatine phosphokinase Creatine kinase Daptomycin business medicine.drug incidence prediction model
Zdroj:	Open Forum Infectious Diseases
ISSN:	2328-8957
Popis:	Background In this study, we investigated the risk factors for daptomycin-associated creatine phosphokinase (CPK) elevation and established a risk score for CPK elevation. Methods Patients who received daptomycin at our hospital were classified into the non-elevated or elevated CPK group based on their peak CPK levels during daptomycin therapy. Univariable and multivariable analyses were performed, and a risk score and prediction model for the incidence probability of CPK elevation were calculated based on logistic regression analysis. Results The non-elevated and elevated CPK groups included 181 and 17 patients, respectively. Logistic regression analysis revealed that concomitant statin use (odds ratio [OR], 4.45 [95% confidence interval {CI}, 1.40–14.47]; risk score 4), concomitant antihistamine use (OR, 5.66 [95% CI, 1.58–20.75]; risk score 4), and trough concentration (Cmin) between 20 and Conclusions These results suggested that concomitant use of statins with antihistamines and Cmin ≥20 µg/mL were risk factors for daptomycin-associated CPK elevation. Our prediction model might aid in reducing the incidence of daptomycin-associated CPK elevation.
Databáze:	OpenAIRE
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