Metachronous metastasis to inguinal lymph nodes from sigmoid colon adenocarcinoma with abdominal wall metastasis: a case report

Autor: Dai Shida, Hirokazu Taniguchi, Shunsuke Tsukamoto, Goki Morizono, Taro Tanabe, Yukihide Kanemitsu
Rok vydání: 2019
Předmět:
Adult
0301 basic medicine
Cancer Research
medicine.medical_specialty
Colorectal cancer
Biopsy
Inguinal Canal
Case Report
External iliac lymph nodes
Adenocarcinoma
Abdominal wall metastasis
lcsh:RC254-282
Multimodal Imaging
Metastasis
Abdominal wall
03 medical and health sciences
Fatal Outcome
0302 clinical medicine
Sigmoidectomy
Antineoplastic Combined Chemotherapy Protocols
Biomarkers
Tumor
Genetics
medicine
Humans
Neoplasm Metastasis
Lymph node
Inguinal lymph node metastasis
business.industry
Abdominal Wall
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Primary tumor
digestive system diseases
Colon cancer
Sigmoid Neoplasms
030104 developmental biology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Female
Lymph Nodes
Radiology
business
Zdroj: BMC Cancer
BMC Cancer, Vol 19, Iss 1, Pp 1-5 (2019)
ISSN: 1471-2407
DOI: 10.1186/s12885-019-5386-x
Popis: Background Inguinal lymph node metastasis from rectum is uncommon but well-known occurrence, whereas that from colon adenocarcinoma is extremely rare. Inguinal lymph node metastasis from colon adenocarcinoma has only been reported in previous cases involving primary tumor invasion of the abdominal wall, or in those involving colon cancer metastasis to external iliac lymph nodes. We describe a case of inguinal lymph node metastasis from colon cancer without primary tumor invasion to the abdominal wall. Case presentation A 42-year-old female, who had undergone twice cesarean sections before, underwent open sigmoidectomy for sigmoid colon adenocarcinoma and received 12 cycles of FOLFOX regimen as adjuvant chemotherapy. Two years after sigmoidectomy, a follow-up CT scan revealed enlarged inguinal lymph nodes as well as growth of enhanced mass lesions on the abdominal wall at site of the cesarean section scar. Biopsy of both lesions revealed well-differentiated adenocarcinoma, and immunohistochemistry demonstrated positive expression of CDX2, substantiating its gastrointestinal origin. We therefore performed dissection of left inguinal lymph nodes and mass lesion of the abdominal wall. The patient died 51 months after lymph node dissection. Conclusions This is the first reported case of inguinal lymph node metastasis from colon cancer without invasion of the primary tumor to the abdominal wall or without involvement of the external iliac lymph nodes, suggesting that the pathway of inguinal metastasis originated from the abdominal wall metastasis. When inguinal lymph node metastasis from colon cancer is suspected, if an R0 resection was possible, inguinal lymph node dissection may be a potentially effective treatment. Electronic supplementary material The online version of this article (10.1186/s12885-019-5386-x) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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