Production and characterisation of bacterial cellulose hydrogels loaded with curcumin encapsulated in cyclodextrins as wound dressings
| Autor: | Ibrahim R Khalil, Hazel Gibson, Xintao Shuai, Daniel J. Keddie, Abhishek Gupta, Vinodh Kannappan, Claire Martin, Iza Radecka, Marek Kowalczuk |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Polymers and Plastics
Gluconacetobacter xylinus General Physics and Astronomy 02 engineering and technology 010402 general chemistry 01 natural sciences chemistry.chemical_compound polycyclic compounds Materials Chemistry QD Cellulose Solubility chemistry.chemical_classification Cyclodextrin Organic Chemistry technology industry and agriculture 021001 nanoscience & nanotechnology R1 QR 0104 chemical sciences carbohydrates (lipids) chemistry Chemical engineering Bacterial cellulose Self-healing hydrogels Curcumin 0210 nano-technology Wound healing |
| Zdroj: | European Polymer Journal. 118:437-450 |
| ISSN: | 0014-3057 |
| DOI: | 10.1016/j.eurpolymj.2019.06.018 |
| Popis: | Natural bioactive materials with wound healing properties such as curcumin are attracting interest due to the emergence of resistant bacterial strains. The hydrophobicity of curcumin has been counteracted by using solubility enhancing cyclodextrins. Hydrogels facilitate wound healing due to unique properties and 3D network structures which allows encapsulation of healing agents. In this study, biosynthetic cellulose produced by Gluconacetobacter xylinus (ATCC 23770) was loaded with water soluble curcumin:hydroxypropyl-β-cyclodextrin supramolecular inclusion complex produced by a solvent evaporation method to synthesise hydrogel dressings. The ratios of solvents to solubilise curcumin and hydroxypropyl-β-cyclodextrin were tested for the production of the inclusion complex with optimum encapsulation efficacy. The results confirmed that hydroxypropyl-β-cyclodextrin enhanced the aqueous solubility of curcumin and allowed loading into bacterial cellulose hydrogels. These hydrogels were characterised for wound management applications and exhibited haemocompatability, cytocompatability, anti-staphylococcal and antioxidant abilities and therefore support the potential use of the curcumin:hydroxypropyl-β-cyclodextrin-loaded-bacterial cellulose as hydrogel dressings. |
| Databáze: | OpenAIRE |
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