CORTICOTROPHIC STUDIES WITH ASPIRIN

Autor:	Taylor J, Old Lj, George R, Way El
Rok vydání:	1962
Předmět:	Aspirin medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Ascorbic Acid Endocrinology Pituitary Gland Anterior Pituitary Gland Vitamin C metabolism Internal medicine Adrenal Glands Humans Medicine business medicine.drug
Zdroj:	Journal of Endocrinology. 24:7-16
ISSN:	1479-6805 0022-0795
Popis:	SUMMARY The effect of aspirin in reducing adrenal ascorbic acid in Sprague—Dawley rats was studied using each animal as its own control. The response to aspirin was blocked by lesions in the region of the median eminence and by hypophysectomy. Removal of the pars nervosa also resulted in depression of the response in the majority of cases. In normal animals the dose of aspirin which produced marked reduction of adrenal ascorbic acid failed to promote antidiuresis. It was concluded that pituitary-adrenal activation by aspirin is mediated via the hypothalamus and that release of the antidiuretic hormone is not essential for this effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a5444dc968a159fdae80cea6b941c4 https://doi.org/10.1677/joe.0.0240007 Zobrazit plný text záznamu