Role of Tumor Suppressor PTEN and Its Regulation in Malignant Transformation of Endometrium

Autor:	Alina M. Perevalova, Vyacheslav S. Kobelev, Virab G. Sisakyan, Lyudmila F. Gulyaeva, Vladimir O. Pustylnyak
Rok vydání:	2022
Předmět:	Biophysics PTEN Phosphohydrolase General Medicine Biochemistry Biochemistry Genetics and Molecular Biology (miscellaneous) Endometrial Neoplasms Phosphatidylinositol 3-Kinases Cell Transformation Neoplastic Humans Female Genes Tumor Suppressor Geriatrics and Gerontology Proto-Oncogene Proteins c-akt Signal Transduction
Zdroj:	Biochemistry. Biokhimiia. 87(11)
ISSN:	1608-3040
Popis:	Tumor-suppressive effects of PTEN are well-known, but modern evidence suggest that they are not limited to its ability to inhibit pro-oncogenic PI3K/AKT signaling pathway. Features of PTEN structure facilitate its interaction with substrates of different nature and display its activity in various ways both in the cytoplasm and in cell nuclei, which makes it possible to take a broader look at its ability to suppress tumor growth. The possible mechanisms of the loss of PTEN effects are also diverse - PTEN can be regulated at many levels, leading to change in the protein activity or its amount in the cell, while their significance for the development of malignant tumors has yet to be studied. Here we summarize the current data on the PTEN structure, its functions and changes in its regulatory mechanisms during malignant transformation of the cells, focusing on one of the most sensitive to the loss of PTEN types of malignant tumors - endometrial cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a4b0e43e5ddfa133e2a626b24de25a https://pubmed.ncbi.nlm.nih.gov/36509719 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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