Dietary fructose and dyslipidemia
Autor: | Bettina Hieronimus, Kimber L. Stanhope |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Small dense ldl Apolipoprotein B Endocrinology Diabetes and Metabolism Fructose 030204 cardiovascular system & hematology Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Dietary Carbohydrates Genetics medicine Animals Humans Insulin secretion Molecular Biology Dyslipidemias Apolipoprotein C-III Nutrition and Dietetics biology Triglyceride Chemistry Cell Biology medicine.disease 030104 developmental biology Postprandial Endocrinology Sweetening Agents biology.protein Apolipoprotein CIII Cardiology and Cardiovascular Medicine Dyslipidemia |
Zdroj: | Curr Opin Lipidol |
ISSN: | 0957-9672 |
Popis: | Purpose of review Chronic consumption of fructose and fructose-containing sugars leads to dyslipidemia. Apolipoprotein (apo) CIII is strongly associated with elevated levels of triglycerides and cardiovascular disease risk. We reviewed the effects of fructose consumption on apoCIII levels and the role of apoCIII in fructose-induced dyslipidemia. Recent findings Consumption of fructose increases circulating apoCIII levels compared with glucose. The more marked effects of fructose compared with glucose on apoCIII concentrations may involve the failure of fructose consumption to stimulate insulin secretion. The increase in apoCIII levels after fructose consumption correlates with increased postprandial serum triglyceride. Further, RNA interference of apoCIII prevents fructose-induced dyslipidemia in nonhuman primates. Increases in postprandial apoCIII after fructose, but not glucose consumption, are positively associated with elevated triglycerides in large triglyceride-rich lipoproteins and increased small dense LDL levels. Summary ApoCIII might be causal in the lipid dysregulation observed after consumption of fructose and fructose-containing sugars. Decreased consumption of fructose and fructose-containing sugars could be an effective strategy for reducing circulating apoCIII and subsequently lowering triglyceride levels. |
Databáze: | OpenAIRE |
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