Is Longevity a Heritable Trait? Evidence for Non-genomic Influence from an Extended Longevity Phenotype of Drosophila melanogaster
| Autor: | Saraf R. Ramesh, S Deepashree, Thimmappa Shivanandappa |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Male Heredity Time Factors Genotype Reciprocal cross media_common.quotation_subject Longevity Overdominance Biology Quantitative trait locus 03 medical and health sciences Sexual Behavior Animal Sex Factors Inbred strain Hybrid Vigor Animals Drosophila media_common Genetics fungi Maternal effect Genetic Variation Heritability biology.organism_classification 030104 developmental biology Drosophila melanogaster Phenotype Evolutionary biology Pediatrics Perinatology and Child Health Female Gene-Environment Interaction |
| Zdroj: | Current aging science. 11(1) |
| ISSN: | 1874-6128 |
| Popis: | BACKGROUND Although genetic variations are heritable, some quantitative traits like longevity may have non-genomic influence on heritability. Laboratory-selected inbred strains of extended longevity phenotype of Drosophila offer an opportunity to study the inheritance of longevity. OBJECTIVE The aim of the study was to examine the heritability of longevity in an extended longevity phenotype of Drosophila melanogaster using reciprocal cross effects in F1 and F2 generations. METHODS Lifespan variations of virgin and mated flies in parent, F1 and F2 generations were investigated using reciprocal crosses between normal and long lifespan lines of inbred population of D. melanogaster. Heterosis, narrow-sense heritability, recombination loss, maternal effect and overdominance with respect to survivorship in virgin and mated flies were analyzed. RESULTS Virgin flies lived longer than mated flies. There was no significant effect of mid-parent heterosis, recombination loss and overdominance on variations in longevity, whereas, significant maternal effect and narrow-sense heritability were observed in mated and virgin flies, respectively. CONCLUSION Absence of heterosis in our study population of Drosophila phenotypes could be due to the lack of genetic heterogeneity. The heritability of the longevity trait in an inbred extended longevity phenotype depends on the variations in genetic and environmental factors. |
| Databáze: | OpenAIRE |
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