Comment on: Kadomoto, S. et al. 'Tumor-Associated Macrophages Induce Migration of Renal Cell Carcinoma Cells via Activation of the CCL20-CCR6 Axis' Cancers 2020, 12, 89
| Autor: | Karin Zins, Dietmar Abraham |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Stromal cell Transition (genetics) Chemistry hemic and immune systems C-C chemokine receptor type 6 medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens lcsh:RC254-282 CCL20 03 medical and health sciences 030104 developmental biology 0302 clinical medicine n/a Oncology Stroma Renal cell carcinoma 030220 oncology & carcinogenesis Cancer research medicine |
| Zdroj: | Cancers, Vol 12, Iss 2, p 342 (2020) |
| ISSN: | 2072-6694 |
| Popis: | Macrophages form a major component of the leukocyte infiltrate in solid tumors and it has become increasingly clear that tumor-associated macrophages (TAMs) have tumor-promoting effects within the stroma [1]. Renal cell carcinoma (RCC) solid tumors are comprised of a heterogeneous microenvironment of both malignant and normal stromal cells containing large numbers of macrophages [2].We read with interest the paper by Suguru Kadomoto et al. entitled "Tumor-associated macrophages induce migration of renal cell carcinoma cells via activation of the CCL20-CCR6 axis", published in Cancers [3], in which they report that the CCL20-CCR6 axis induces migration and epithelial-mesenchymal transition (EMT) of ACHN and Caki-1 RCC cells in co-cultures with THP-1/U937-derived tumor conditioned macrophages.[...]. |
| Databáze: | OpenAIRE |
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