INFLUENCES OF TEMPORAL LOBE EPILEPSY AND TEMPORAL LOBE RESECTION ON OLFACTION
| Autor: | Bruce I. Turetsky, John Pluta, Jonathan Silas, Isabelle Tourbier, Michael Sperling, Taehoon Kim, Richard L. Doty, Paul J. Moberg, Ashwini Sharan, John A. Detre, Natasha Mirza, Jessica K. Neff, Jacqueline A. French, Gordon H. Baltuch, Anthony H. Risser |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Neurology Odor detection threshold Adolescent Anosmia Hippocampus Olfaction Audiology Article Functional Laterality Temporal lobe 03 medical and health sciences Epilepsy chemistry.chemical_compound Olfaction Disorders Young Adult 0302 clinical medicine medicine Humans Aged business.industry Middle Aged medicine.disease Anterior Temporal Lobectomy Olfactory Perception Temporal Lobe 030104 developmental biology chemistry Odor Epilepsy Temporal Lobe Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery psychological phenomena and processes |
| Popis: | Although temporal lobe epilepsy (TLE) and resection (TLR) impact olfactory eloquent brain structures, their influences on olfaction remain enigmatic. We sought to more definitively assess the influences of TLE and TLR on olfaction using three well-validated olfactory tests and measuring the tests’ associations with the volume of numerous temporal lobe brain structures. The University of Pennsylvania Smell Identification Test and an odor detection threshold test were administered to 71 TLE patients and 71 age- and sex-matched controls; 69 TLE patients and controls received an odor discrimination/memory test. Fifty-seven patients and 57 controls were tested on odor identification and threshold before and after TLR; 27 patients and 27 controls were similarly tested for odor detection/discrimination. Scores were compared using analysis of variance and correlated with pre- and post-operative volumes of the target brain structures. TLE was associated with bilateral deficits in all test measures. TLR further decreased function on the side ipsilateral to resection. The hippocampus and other structures were smaller on the focus side of the TLE subjects. Although post-operative volumetric decreases were evident in most measured brain structures, modest contralateral volumetric increases were observed in some cases. No meaningful correlations were evident pre- or post-operatively between the olfactory test scores and the structural volumes. In conclusion, we demonstrate that smell dysfunction is clearly a key element of both TLE and TLR, impacting odor identification, detection, and discrimination/memory. Whether our novel finding of significant post-operative increases in the volume of brain structures contralateral to the resection side reflects plasticity and compensatory processes requires further study. |
| Databáze: | OpenAIRE |
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