Functionalization of biomedical materials using fusion peptides for tissue regeneration

Autor: Xiaolei Guo, Yuan Ma, A Ruhan, Shuo Pan, Yajuan Guo, Xinli Shi, Guobiao Gao, Lei Sun, Jiadao Wang
Rok vydání: 2022
Předmět:
Zdroj: Biomedical Materials. 17:062003
ISSN: 1748-605X
1748-6041
Popis: Tissue development deformity or tissue defect is a major clinical challenge. Tissue engineering technology provides a promising solution to these problems. Among them, functional biomaterials with regenerative abilities are one of the development trends. Polypeptide is a small molecule that can be used to modify tissue engineering materials. However, the function of a single polypeptide molecule is limited and insufficient to construct comprehensive microenvironment for tissue regeneration. Fusion peptides combining two or more polypeptide molecules with different functions were expected to achieve multiple efficacies in vivo, providing a novel solution for clinical tissue regeneration engineering applications. This paper reviews the construction methods, degradation process, and biological activities of fusion peptides, and presents recent global research progress and prospects concerning fusion peptides. It provides a reference helping to guide the future exploration and development of fusion peptide-based functional biomaterials for tissue engineering.
Databáze: OpenAIRE