MDMA (ecstasy) effects in pubescent rats: Males are more sensitive than females

Autor: Sami Ben Hamida, Céline Riegert, Julie Koenig, Christian Kelche, Byron C. Jones, Jean-Christophe Cassel, Hélène Jeltsch, Christine Lazarus
Přispěvatelé: IFR de neurosciences de Strasbourg (INS), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Imagerie et de Neurosciences Cognitives (LINC), Université Louis Pasteur - Strasbourg I-IFR37-Centre National de la Recherche Scientifique (CNRS), Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université] (INMED - INSERM U1249), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Jazyk: angličtina
Rok vydání: 2005
Předmět:
Male
Time Factors
Dopamine
[SDV]Life Sciences [q-bio]
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Clinical Biochemistry
Ecstasy
Toxicology
Biochemistry
Body Temperature
Norepinephrine
Random Allocation
Behavioral Neuroscience
0302 clinical medicine
Hippocampus (mythology)
MESH: Animals
Sexual Maturation
Chromatography
High Pressure Liquid
ComputingMilieux_MISCELLANEOUS
0303 health sciences
Brain
MDMA
Hydroxyindoleacetic Acid
MESH: Motor Activity
Survival Rate
Dose–response relationship
Female
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Psychology
psychological phenomena and processes
medicine.drug
Hyperthermia
Serotonin
medicine.medical_specialty
Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]
MESH: Ethanol
MESH: Rats
N-Methyl-3
4-methylenedioxyamphetamine
Motor Activity
03 medical and health sciences
Sex Factors
MESH: Rats
Long-Evans
Internal medicine
MESH: Fever
mental disorders
medicine
Animals
Rats
Long-Evans
Biological Psychiatry
030304 developmental biology
MESH: Drug Combinations
Pharmacology
Dose-Response Relationship
Drug
medicine.disease
MESH: Male
Rats
Sexual dimorphism
Endocrinology
3
4-Dihydroxyphenylacetic Acid
MESH: N-Methyl-3
4-methylenedioxyamphetamine
030217 neurology & neurosurgery
Zdroj: Pharmacology Biochemistry and Behavior
Pharmacology Biochemistry and Behavior, Elsevier, 2005, 81 (3), pp.635-644. ⟨10.1016/j.pbb.2005.04.014⟩
Pharmacology Biochemistry and Behavior, 2005, 81 (3), pp.635-644. ⟨10.1016/j.pbb.2005.04.014⟩
ISSN: 0091-3057
DOI: 10.1016/j.pbb.2005.04.014⟩
Popis: In Experiment 1, we assessed the effects of 3,4-methylenedioxymethamphetamine (MDMA) on locomotor activity in pubescent male and female Long-Evans rats. Thirty-nine day old rats were injected ip with 10 mg/kg of MDMA (ambient temperature 25 degrees C) three times at 2 h intervals. Initially, females showed greater locomotor activation by the drug than males, however after the second injection, males showed greater hyperlocomotion. After the third injection, 3 of 10 females and all of the males died. In the surviving females, we observed serotonin depletion in cortex and hippocampus, but catecholaminergic markers were unaltered. In Experiment 2, male and female rats were repeatedly injected with saline or 2, 5 or 10 mg/kg MDMA and body temperature was measured (ambient temperature 21.5 degrees C). After the third injection of 10 mg/kg MDMA, the MDMA-induced hyperthermia was greater in males than in females (about +0.8 degrees C); at the lower dose, no difference was observed. Probably because of the lower ambient temperature, only 1 female and 2 males succumbed to the MDMA treatment, and MDMA induced less serotonin depletion than in the first experiment, with no difference between females and males. Thus, pubescent males appear to be more sensitive than females to locomotor and hyperpyretic effects of MDMA. This sex-dependent effect, which is at variance with previously reported dimorphisms in psychostimulant effects, is discussed in terms of possible differences in dopamine D1 and D2 receptors at pubescence, or other factors related to drug metabolism.
Databáze: OpenAIRE
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