Aqueous seed extract of Cola nitida rubra reduces serum reproductive hormone concentrations and sperm count in adult male albino Wistar rats
| Autor: | Victor Udo Nna, O A Emmanuel, I O Umoh |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
biology Adult male Cola nitida ved/biology ved/biology.organism_classification_rank.species General Medicine sperm count biology.organism_classification Epididymis Sperm Cola (plant) Andrology Endocrinology medicine.anatomical_structure Internal medicine testosterone medicine luteinizing hormone Original Article Luteinizing hormone Testosterone Hormone |
| Zdroj: | Nigerian Medical Journal : Journal of the Nigeria Medical Association |
| ISSN: | 0300-1652 |
| Popis: | Background: Following the high rate of consumption of Cola nitida (cola nut) among the male population in Nigeria, this study seeks to determine the effects of consumption of Cola nitida on serum reproductive hormones and sperm count, which are major determinants of male fertility. Materials and Methods: Thirty-two male albino wistar rats weighing 180-220 g were used for this study and were divided into 4 groups of eight animals each. Group 1 served as control, group 2 received 2 mg/kg Cola nitida extract (Test 1), group 3 received 6 mg/kg Cola nitida extract (Test 2) and group 4 received 10 mg/kg Cola nitida extract (Test 3). After 6 weeks of treatment, reproductive hormonal assay was carried out using the rat serum. Epididymal spermatozoa were collected and sperm count determined. Results: Serum concentrations of luteinizing hormone (LH) and testosterone were significantly (P < 0.05) reduced in test 2 and 3, compared with control. Sperm count was significantly lower in test group 1 (P < 0.05), 2 (P < 0.001) and 3 (P < 0.001) compared with control, with test 3 significantly (P < 0.05) lower compared with test 1. There was no significant difference in testicular and epididymis weight in the different experimental groups studied. Conclusion: Aqueous seed extract of Cola nitida rubra resulted in reduced serum reproductive hormone concentrations and sperm count in male wistar rats, and may therefore be detrimental to reproductive health, hence the need for regulation of its consumption. |
| Databáze: | OpenAIRE |
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