Safe Negative Margin Width in Breast Conservative Therapy: Results from a Population with a High Percentage of Negative Prognostic Factors
| Autor: | Narjis Muzaffar, Aamir Ali Syed, Amina Iqbal Khan, Awais Aamir, Abu Bakar Hafeez Bhatti, M. A. Shah, Neelam Siddiqui, Arif Jamshed |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Neoplasm Residual Multivariate analysis Population Sentinel lymph node Breast Neoplasms Mastectomy Segmental Disease-Free Survival Young Adult Margin (machine learning) Humans Medicine Pakistan Breast education Aged Neoplasm Staging Retrospective Studies Aged 80 and over education.field_of_study business.industry Carcinoma Ductal Breast Cancer Middle Aged medicine.disease Clavicle Tumor Burden Surgery Axilla medicine.anatomical_structure Cardiothoracic surgery Lymphatic Metastasis Female Radiology Neoplasm Grading Neoplasm Recurrence Local business Carcinoma in Situ Abdominal surgery |
| Zdroj: | World Journal of Surgery. 38:2863-2870 |
| ISSN: | 1432-2323 0364-2313 |
| Popis: | There remains a controversy in the literature regarding adequate width of negative surgical margins in breast conservative therapy (BCT). It is now advocated that no tumor on an inked margin is a safe negative margin. Majority of studies on the outcomes of BCT had patients with favorable prognostic factors. Pakistani population has a high expression of unfavorable prognostic factors. The objective of this study was to determine a safe negative margin width in Pakistani population that undergoes BCT. A total of 603 patients with identifiable surgical margins underwent BCT from 1997 to 2009 in Shaukat Khanum Cancer Hospital. Patients were divided into close (≤2 mm), free (>2–10 mm), and wide (>10 mm) margin groups. Locoregional recurrence was defined as recurrence within the operated breast, ipsilateral axilla, or supraclavicular or internal mammary lymph nodes. Locoregional recurrence-free survival was calculated from the date of surgery to the date of locoregional recurrence. Five-year locoregional recurrence-free survival was determined for margin groups. Univariate and multivariate Cox proportional hazard analyses were performed to determine independent predictors of locoregional recurrence. A total of 415 (69 %) patients were |
| Databáze: | OpenAIRE |
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