The Oxford IgA nephropathy clinicopathological classification is valid for children as well as adults
| Autor: | Coppo, R., Troyanov, S., Camilla, R., Hogg, R.J., Cattran, D.C., Cook, H.T., Feehally, J., Roberts, I.S.D., Amore, A., Alpers, C.E., Barratt, J., Berthoux, F., Bonsib, S., Bruijn, J.A., D'Agati, V., D'Amico, G., Emancipator, S.N., Emma, F., Ferrario, F., Fervenza, F.C., Florquin, S., Fogo, A.B., Geddes, C.C., Groene, H.J., Haas, M., Herzenberg, A.M., Hill, P.A., Hsu, S.I., Jennette, J.C., Joh, K., Julian, B.A., Kawamura, T., Lai, F.M., Li, L.S., Li, P.K., Liu, Z.H., Mezzano, S., Schena, F.P., Tomino, Y., Walker, P.D., Wang, H.Y., Weening, J.J., Yoshikawa, N., Zhang, H., Int igA Nephropathy Network, Renal Pathology Soc |
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| Přispěvatelé: | Psychiatry, Pathology, AII - Amsterdam institute for Infection and Immunity, Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Biopsy Renal function Kidney Kidney Function Tests urologic and male genital diseases Gastroenterology Nephropathy Glomerulonephritis children renal biopsy Internal medicine medicine Humans Child children histopathology IgA nephropathy renal biopsy glomerular-filtration-rate prognostic indicators renal biopsies features japanese Hematuria Proteinuria medicine.diagnostic_test business.industry Glomerulonephritis IGA IgA nephropathy medicine.disease Nephrology Chronic Disease Cohort histopathology Female Histopathology Renal biopsy medicine.symptom business Immunosuppressive Agents |
| Zdroj: | Kidney International, 77(10), 921-927 KIDNEY INTERNATIONAL Artículos CONICYT CONICYT Chile instacron:CONICYT Kidney International, 77(10), 921-927. Elsevier Inc. Kidney international, 77(10), 921-927. Nature Publishing Group |
| ISSN: | 0085-2538 |
| Popis: | To study the predictive value of biopsy lesions in IgA nephropathy in a range of patient ages we retrospectively analyzed the cohort that was used to derive a new classification system for IgA nephropathy. A total of 206 adults and 59 children with proteinuria over 0.5 g/24h/1.73 m(2) and an eGFR of stage-3 or better were followed for a median of 69 months. At the time of biopsy, compared with adults children had a more frequent history of macroscopic hematuria, lower adjusted blood pressure, and higher eGFR but similar proteinuria. Although their outcome was similar to that of adults, children had received more immunosuppressants and achieved a lower follow-up proteinuria. Renal biopsies were scored for variables identified by an iterative process as reproducible and independent of other lesions. Compared with adults, children had significantly more mesangial and endocapillary hypercellularity, and less segmental glomerulosclerosis and tubulointerstitial damage, the four variables previously identified to predict outcome independent of clinical assessment. Despite these differences, our study found that the cross-sectional correlation between pathology and proteinuria was similar in adults and children. The predictive value of each specific lesion on the rate of decline of renal function or renal survival in IgA nephropathy was not different between children and adults. Kidney International (2010) 77, 921-927; doi: 10.1038/ki.2010.43; published online 3 March 2010 |
| Databáze: | OpenAIRE |
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