Electrospinnability of Poly Lactic-co-glycolic Acid (PLGA): the Role of Solvent Type and Solvent Composition

Autor: Lars Porskjær Christensen, Johanna Aho, Jukka Rantanen, Haiyan Qu, Stefania Baldursdottir, Xiaoli Liu, Mingshi Yang
Rok vydání: 2016
Předmět:
Materials science
rheological property
Lactic Acid/chemistry
Nanofibers
Pharmaceutical Science
02 engineering and technology
010402 general chemistry
01 natural sciences
Surface tension
chemistry.chemical_compound
Drug Delivery Systems
Polylactic Acid-Polyglycolic Acid Copolymer
morphology
Polymer chemistry
Ultimate tensile strength
Pharmacology (medical)
Lactic Acid
electrospinning
Glycolic acid
Mechanical Phenomena
Pharmacology
chemistry.chemical_classification
Organic Chemistry
Nanofibers/chemistry
Polymer
021001 nanoscience & nanotechnology
Electrospinning
Solvents/chemistry
0104 chemical sciences
Solvent
Molecular Weight
mechanical property
PLGA
Chemical engineering
chemistry
Solvents
Molecular Medicine
Dimethylformamide
Polyglycolic Acid/chemistry
0210 nano-technology
Rheology
Polyglycolic Acid
Biotechnology
Zdroj: Liu, X, Baldursdottir, S G, Aho, J, Qu, H, Christensen, L P, Rantanen, J & Yang, M 2017, ' Electrospinnability of poly lactic-co-glycolic acid (PLGA) : the role of solvent type and solvent composition ', Pharmaceutical Research, vol. 34, no. 4, pp. 738-749 . https://doi.org/10.1007/s11095-017-2100-z
ISSN: 1573-904X
DOI: 10.1007/s11095-017-2100-z
Popis: Purpose: In this study, the electrospinnability of poly(lactic-co-glycolic acid) (PLGA) solutions was investigated, with a focus on understanding the influence of molecular weight of PLGA, solvent type and solvent composition on the physical properties of electrospun nanofibers. Method: Various solvents were tested to dissolve two PLGA grades (50 KDa-RG755, 100 KDa-RG750). The viscoelasticity, surface tension, and evaporation rate of the PLGA solutions were characterized prior to the electrospinning process. The resulting electrospun nanofibers were characterized with respect to the morphology and mechanical properties. Results: Two pairs of solvent mixtures, i.e. dimethylformamide (DMF)—tetrahydrofuran (THF) and DMF—chloroform (CHL), were identified to provide a stable cone-jet. Within the polymer concentration range studied (10–30%, w/v), RG750 solutions could be electrospun into uniform fibers at 30% (w/v) or at 20% (w/v) when modifying the solvent composition. In comparison to DMF-THF solution, fibers had larger diameter, higher stiffness and tensile strength when electrospun from DMF-CHL solution. Conclusion: The high molecular weight polymer could ensure sufficient intermolecular interaction to generate uniform fibers. The solvent could influence the morphology and mechanical properties of the electrospun fibers by altering the properties of PLGA solution, and drying rate of fibers in the electrospinning process.
Databáze: OpenAIRE
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