Approaches to Short-Acting Neuromuscular Blocking Agents: Nonsymmetrical Bis-tetrahydroisoquinolinium Mono- and Diesters
Autor: | William B. Wastila, John B. Stenlake, Nirmal C. Dhar, John M. Midgley, Luke A. Masterson, R. B. Maehr |
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Rok vydání: | 1996 |
Předmět: |
Magnetic Resonance Spectroscopy
Chemistry Stereochemistry Hydrolysis Quinolinium Compounds Esters Vagus Nerve Isoquinolines Neuromuscular Blocking Agents Chemical synthesis Vagal blockade Drug Discovery Cats Atracurium besilate medicine Animals Molecular Medicine Moiety Chromatography Thin Layer medicine.drug |
Zdroj: | Journal of Medicinal Chemistry. 39:556-561 |
ISSN: | 1520-4804 0022-2623 |
Popis: | Nonsymmetrical bisquaternary mono- and diesters combining the potency-enhancing properties of the (1R)-laudanosinium group with a second unhindered quaternary ammonium moiety have been studied as a means of promoting short action with high-potency neuromuscular block. Atracurium-related nonsymmetrical diesters showed high potency, freedom from vagal blockade at neuromuscular blocking doses, and short action. Nonsymmetrical monoesters were short acting but showed varying degrees of vagal block. |
Databáze: | OpenAIRE |
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