Molecular definition of the identity and activation of natural killer cells
| Autor: | Bezman, Natalie A., Kim, Charles C., Sun, Joseph C., Min-Oo, Gundula, Hendricks, Deborah W., Kamimura, Yosuke, Best, J. Adam, Goldrath, Ananda W., Lanier, Lewis L., Regev, Aviv, Immunological Genome Project Consortium |
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| Přispěvatelé: | Massachusetts Institute of Technology. Department of Biology, Regev, Aviv |
| Rok vydání: | 2012 |
| Předmět: |
Transcription
Genetic T-Lymphocytes Immunology Biology Lymphocyte Activation Article CD49b Mice 03 medical and health sciences Interleukin 21 0302 clinical medicine Animals Humans Immunology and Allergy Antigen-presenting cell Cells Cultured 030304 developmental biology Genetics 0303 health sciences Lymphokine-activated killer cell Gene Expression Profiling Janus kinase 3 Cell Differentiation Natural killer T cell 3. Good health Cell biology Killer Cells Natural Interleukin 12 Myeloid-derived Suppressor Cell Signal Transduction 030215 immunology |
| Zdroj: | PMC Nature immunology |
| ISSN: | 1529-2916 1529-2908 |
| DOI: | 10.1038/ni.2395 |
| Popis: | available in PMC 2013 April 01. Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cells are known to share expression of a few genes with cytotoxic CD8+ T cells, our transcriptome-wide analysis demonstrates that the commonalities extend to hundreds of genes, many encoding molecules with unknown functions. Resting NK cells demonstrate a 'preprimed' state compared with naive T cells, which allows NK cells to respond more rapidly to viral infection. Collectively, our data provide a global context for known and previously unknown molecular aspects of NK cell identity and function by delineating the genome-wide repertoire of gene expression of NK cells in various states. National Institute of Allergy and Infectious Diseases (U.S.) (NIH (R24 AI072073)) National Institute of Allergy and Infectious Diseases (U.S.) (NIH (R01 AI068129)) National Institute of Allergy and Infectious Diseases (U.S.) (NIH (T32AI060537)) National Institute of Allergy and Infectious Diseases (U.S.) (NIH (AI072117)) Canadian Institutes of Health Research American Cancer Society Searle Scholars Program |
| Databáze: | OpenAIRE |
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