Early-to-mid idiopathic Parkinson’s disease shows a more cytotoxic but declined CD8-regulatory peripheral immune profile
| Autor: | Christophe Capelle, Séverine Cire, Maxime Hansen, Lukas Pavelka, Fanny Hedin, Maria Konstantinou, Dominique Revets, Vera Tslaf, Taina Marques, Alexandre Baron, Olivia Domingues, Ni Zeng, Patrick May, Antonio Cosma, Rudi Balling, Rejko Krüger, Markus Ollert, Feng Hefeng |
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| Přispěvatelé: | Fonds National de la Recherche - FnR [sponsor], Luxembourg Personalized Medicine Consortium (PMC) [sponsor], Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) [research center], Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) [research center], Luxembourg Institute of Health - LIH [research center] |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Immunology & infectious disease [D12] [Human health sciences]
Immunologie & maladie infectieuse [D12] [Sciences de la santé humaine] Neurologie [D14] [Sciences de la santé humaine] Neurology [D14] [Human health sciences] Genetics & genetic processes [F10] [Life sciences] Génétique & processus génétiques [F10] [Sciences du vivant] |
| Popis: | Parkinson’s disease (PD) is the second most common neurodegenerative disease. Brain neuroinflammation plays a role in PD pathogenesis. However, the involvement of the peripheral immune system has not been systematically investigated. Here we analyzed >700 combinatorial immunological features in fresh blood of 28 early-to-mid-stage PD patients and 24 matched controls. We found an enhanced cytotoxic immune profile in idiopathic PD patients (iPD), with a higher frequency of terminally-differentiated effector CD8 T (TEMRA), late-differentiated CD8+ natural killer T cells and neutrophils. This immune profile was intensified by elevated serum granzyme A, reduced percentages of CD8+FOXP3+ regulatory T cells and group 2 innate lymphoid cells with immunosuppressive or tolerance-inducing functions. The frequency of CD8 TEMRA was negatively correlated with disease duration, suggesting a contribution to PD pathogenesis. Our work provides a comprehensive map on disturbed peripheral adaptive and innate immune cells in early-to-mid iPD, proposing easily-accessible candidates for early diagnosis and treatments. |
| Databáze: | OpenAIRE |
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