Not on speaking terms: hallucinations and structural network disconnectivity in schizophrenia

Autor: Remco J. Renken, Lisette van der Meer, André Aleman, Luca Nanetti, Leonardo Cerliani, Gerdina H. M. Pijnenborg, Branislava Ćurčić-Blake
Přispěvatelé: Clinical Psychology and Experimental Psychopathology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Perceptual and Cognitive Neuroscience (PCN), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Netherlands Institute for Neuroscience (NIN)
Rok vydání: 2013
Předmět:
Male
Hallucinations
Statistics as Topic
WHITE-MATTER ABNORMALITIES
Corpus callosum
CONNECTIVITY
Neural Pathways
LANGUAGE PATHWAYS
Cingulum (brain)
Arcuate fasciculus
Brain Mapping
biology
General Neuroscience
Superior longitudinal fasciculus
Brain
Anatomy
Middle Aged
White Matter
DIFFUSION
INTEGRITY
medicine.anatomical_structure
Fronto-temporal connectivity
Female
Psychology
psychological phenomena and processes
Adult
Diffusion tensor imaging (DTI)
Histology
Uncinate fasciculus
behavioral disciplines and activities
Lateralization of brain function
White matter
Young Adult
Imaging
Three-Dimensional
Fasciculus
medicine
Humans
Psychiatric Status Rating Scales
Anatomical connectivity
ARCUATE FASCICULUS
TRACTOGRAPHY
biology.organism_classification
BRAIN-STIMULATION
Diffusion Magnetic Resonance Imaging
Thalamo-cortical connectivity
nervous system
Schizophrenia
Anisotropy
Language network
UNCINATE FASCICULUS
Neuroscience
AUDITORY VERBAL HALLUCINATIONS
Zdroj: Brain Structure and Function, 220(1), 407-418. SPRINGER HEIDELBERG
Brain Structure & Function, 220(1), 407-18. Springer Verlag GmbH
ISSN: 1863-2661
1863-2653
Popis: Auditory verbal hallucinations (AVH) in schizophrenia have previously been associated with functional deficiencies in language networks, specifically with functional disconnectivity in fronto-temporal connections in the left hemisphere and in interhemispheric connections between frontal regions. Here, we investigate whether AVH are accompanied by white matter abnormalities in tracts connecting the frontal, parietal and temporal lobes, also engaged during language tasks. We combined diffusion tensor imaging with tract-based spatial statistics and found white matter abnormalities in patients with schizophrenia as compared with healthy controls. The patients showed reduced fractional anisotropy bilaterally: in the anterior thalamic radiation (ATR), body of the corpus callosum (forceps minor), cingulum, temporal part of the superior longitudinal fasciculus (SLF) and a small area in the inferior fronto-occipital fasciculus (IFOF); and in the right hemisphere: in the visual cortex, forceps major, body of the corpus callosum (posterior parts) and inferior parietal cortex. Compared to patients without current hallucinations, patients with hallucinations revealed decreased fractional anisotropy in the left IFOF, uncinate fasciculus, arcuate fasciculus with SLF, corpus callosum (posterior parts-forceps major), cingulate, corticospinal tract and ATR. The severity of hallucinations correlated negatively with white matter integrity in tracts connecting the left frontal lobe with temporal regions (uncinate fasciculus, IFOF, cingulum, arcuate fasciculus anterior and long part and superior long fasciculus frontal part) and in interhemispheric connections (anterior corona radiata). These findings support the hypothesis that hallucinations in schizophrenia are accompanied by a complex pattern of white matter alterations that negatively affect the language, emotion and attention/perception networks.
Databáze: OpenAIRE
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