Association of VEGF +405GC polymorphism with endometriosis
| Autor: | Maria Celestina, Vanaja, Roya, Rozati, Khaja, Nassaruddin, Satti, Vishnupriya |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Vascular Endothelial Growth Factor A
medicine.medical_specialty Genotype Endometriosis India Gastroenterology Polymerase Chain Reaction Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Gene Frequency Internal medicine medicine SNP Animals Adenomyosis Genetic Predisposition to Disease Prospective Studies Gene Genotyping Genetic Association Studies DNA Primers General Immunology and Microbiology business.industry medicine.disease genomic DNA Case-Control Studies Female Restriction fragment length polymorphism business Polymorphism Restriction Fragment Length |
| Zdroj: | Frontiers in bioscience (Elite edition). 5(2) |
| ISSN: | 1945-0508 |
| Popis: | The present study was designed to explore the association between the SNP +405GC of the VEGF gene with the risk of endometriosis, and endometriosis associated with adenomyosis and chocolate cysts. Following extraction of genomic DNA, genotyping of the +405 GC polymorphisms of the VEGF gene was performed by PCR - RFLP analysis. The genotype (X2 =21.713, 2 df, P =0.0001) and allele (X2 =10.697, 1 df, P = 0.0011) frequencies of endometriosis patients were significantly different from those of the control women. The genotype and allele frequencies significantly differed in all the clinical subgroups of endometriosis patients. The significant differences in allele frequencies were the result of an increased proportion of homozygote GG genotype carriers. No significant difference was observed between the clinical subgroups with respect to the genotype and allele frequencies of the VEGF +405GC polymorphism. These findings suggest that the VEGF +405 GC polymorphism is associated with the risk of endometriosis, and endometriosis associated with adenomyosis and chocolate cysts. |
| Databáze: | OpenAIRE |
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