Polyclonal origin of colonic adenomas in an XO/XY patient with FAP
| Autor: | Nicholas A. Wright, Marco Novelli, I. P. M. Tomlinson, I. C. Talbot, G Elia, Shirley Hodgson, Jill Williamson, Walter F. Bodmer |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Adenoma Genotype Colon Y chromosome Familial adenomatous polyposis Intestinal mucosa Ileum Internal medicine Y Chromosome medicine Humans Intestinal Mucosa In Situ Hybridization In Situ Hybridization Fluorescence Multidisciplinary biology Mosaicism Karyotype medicine.disease Molecular biology digestive system diseases Clone Cells Endocrinology Phenotype Adenomatous Polyposis Coli Polyclonal antibodies Karyotyping Monoclonal biology.protein Clone (B-cell biology) DNA Probes |
| Zdroj: | Scopus-Elsevier |
| DOI: | 10.1126/science.272.5265.1187 |
| Popis: | It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examined directly by in situ hybridization with Y chromosome probes. In this patient, the crypts of the small and large intestine were clonal, but at least 76 percent of the microadenomas were polyclonal in origin. |
| Databáze: | OpenAIRE |
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