Reporting preclinical anesthesia study (REPEAT): Evaluating the quality of reporting in the preclinical anesthesiology literature
| Autor: | Tyler E James, Sarah Larrigan, Neil M. Goldenberg, Grace Fox, Ronald B. George, Abhilasha Patel, Dean Fergusson, David Mazer, Ryan McGinn, Sylvain Boet, Stephane L. Bourque, Yuan Yi Dong, Marc T. Avey, Duncan J. Stewart, Prathiba Harsha, Carly C. Barron, Ferrante S. Gragasin, Long Nguyen, Mathew Bocock, Courtney A Manuel, Philippe Richebé, Manoj M. Lalu, Summer Syed, Sonja D Sampson, Kai Chen, Benjamin E. Steinberg, Isidora Conic, Kimberly Vella, Patrick Jiho Hong, Neil Wesch, Jenna MacNeil, Rohan Mittal, Sarah Maximos, Tarit Saha, Kristen E Biefer |
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| Přispěvatelé: | Scherer, Roberta W |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Research Report Databases Factual Drug Evaluation Preclinical Alternative medicine Preclinical research 0302 clinical medicine Anesthesiology Medicine and Health Sciences Anesthesia Analgesics Multidisciplinary Pharmaceutics Experimental Design Pain Research Animal Models Research Assessment Preclinical Experimental Organism Systems Research Design Cohort Research Reporting Guidelines Medicine Research Article medicine.medical_specialty Blinding Randomization General Science & Technology Science MEDLINE Pain Guidelines as Topic Research and Analysis Methods 03 medical and health sciences Databases Drug Therapy medicine Animals Canadian Perioperative Anesthesia Clinical Trials Group Factual Scientific Publishing business.industry 030104 developmental biology Relative risk Animal Studies Drug Evaluation Analgesia business 030217 neurology & neurosurgery |
| Zdroj: | PloS one, vol 14, iss 5 PLoS ONE, Vol 14, Iss 5, p e0215221 (2019) PLoS ONE |
| Popis: | Poor reporting quality may contribute to irreproducibility of results and failed 'bench-to-bedside' translation. Consequently, guidelines have been developed to improve the complete and transparent reporting of in vivo preclinical studies. To examine the impact of such guidelines on core methodological and analytical reporting items in the preclinical anesthesiology literature, we sampled a cohort of studies. Preclinical in vivo studies published in Anesthesiology, Anesthesia & Analgesia, Anaesthesia, and the British Journal of Anaesthesia (2008-2009, 2014-2016) were identified. Data was extracted independently and in duplicate. Reporting completeness was assessed using the National Institutes of Health Principles and Guidelines for Reporting Preclinical Research. Risk ratios were used for comparative analyses. Of 7615 screened articles, 604 met our inclusion criteria and included experiments reporting on 52 490 animals. The most common topic of investigation was pain and analgesia (30%), rodents were most frequently used (77%), and studies were most commonly conducted in the United States (36%). Use of preclinical reporting guidelines was listed in 10% of applicable articles. A minority of studies fully reported on replicates (0.3%), randomization (10%), blinding (12%), sample-size estimation (3%), and inclusion/exclusion criteria (5%). Statistics were well reported (81%). Comparative analysis demonstrated few differences in reporting rigor between journals, including those that endorsed reporting guidelines. Principal items of study design were infrequently reported, with few differences between journals. Methods to improve implementation and adherence to community-based reporting guidelines may be necessary to increase transparent and consistent reporting in the preclinical anesthesiology literature. |
| Databáze: | OpenAIRE |
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