Snapshot hyperspectral retinal imaging using compact spectral resolving detector array
| Autor: | Amani A. Fawzi, Hao Zhang, Biqin Dong, Hao Li, Joel Kaluzny, Wenzhong Liu |
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| Rok vydání: | 2016 |
| Předmět: |
Chemical imaging
Male medicine.medical_specialty Computer science Fundus Oculi General Physics and Astronomy 01 natural sciences General Biochemistry Genetics and Molecular Biology Retina Article 010309 optics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Optics 0103 physical sciences medicine Animals Humans General Materials Science Rats Long-Evans Pixel business.industry Spectrum Analysis General Engineering Hyperspectral imaging Retinal General Chemistry Spectral bands Equipment Design Spectral imaging Oxygen chemistry Full spectral imaging 030221 ophthalmology & optometry Snapshot (computer storage) business |
| Zdroj: | Journal of biophotonics. 10(6-7) |
| ISSN: | 1864-0648 |
| Popis: | Hyperspectral retinal imaging captures the light spectrum from each imaging pixel. It provides spectrally encoded retinal physiological and morphological information, which could potentially benefit diagnosis and therapeutic monitoring of retinal diseases. The key challenges in hyperspectral retinal imaging are how to achieve snapshot imaging to avoid motions between the images from multiple spectral bands, and how to design a compact snapshot imager suitable for clinical use. Here, we developed a compact, snapshot hyperspectral fundus camera for rodents using a novel spectral resolving detector array (SRDA), on which a thin-film Fabry-Perot cavity filter was monolithically fabricated on each imaging pixel. We achieved hyperspectral retinal imaging with 16 wavelength bands (460 to 630 nm) at 20 fps. We also demonstrated false-color vessel contrast enhancement and retinal oxygen saturation (sO2 ) measurement through spectral analysis. This work could potentially bring hyperspectral retinal imaging from bench to bedside. |
| Databáze: | OpenAIRE |
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