Meropenem stability to beta-lactamase hydrolysis and comparative in vitro activity against several beta-lactamase-producing Gram-negative strains

Autor:	L. Franchino, Nicola Franceschini, Mariagrazia Perilli, Gianfranco Amicosante, Bernardetta Segatore, S. Vessillier
Rok vydání:	2002
Předmět:	Microbiology (medical) Imipenem Gram-negative bacteria Microbial Sensitivity Tests medicine.disease_cause Meropenem beta-Lactamases Microbiology Gram-Negative Bacteria polycyclic compounds medicine Pharmacology (medical) Biapenem Escherichia coli Antibacterial agent Pharmacology chemistry.chemical_classification biology Hydrolysis Biological activity biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Enzyme Activation Infectious Diseases Enzyme chemistry bacteria Thienamycins medicine.drug
Zdroj:	Journal of Antimicrobial Chemotherapy. 49:395-398
ISSN:	1460-2091
DOI:	10.1093/jac/49.2.395
Popis:	The interaction between meropenem and class A, B, C and D beta-lactamases was studied by a spectrophotometric method. Class A, C and D beta-lactamases were unable to confer in vitro resistance to carbapenems. Surprisingly, several class B metallo-beta-lactamases expressed in Escherichia coli failed to confer resistance when a conventional inoculum (105 cfu/mL) was used.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7581d19b6427b7137423f4c1b8da246e https://doi.org/10.1093/jac/49.2.395 Zobrazit plný text záznamu