Preparation and evaluation of MRI detectable poly (acrylic acid) microspheres loaded with superparamagnetic iron oxide nanoparticles for transcatheter arterial embolization
| Autor: | Zhuo-Zhao Zheng, Tian-Yuan Fan, Xiao-Ya Qin, Li-Si Liu, Li-Ying Guo, Zi-Yuan Li, Huan Wang |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Materials science Injections Subcutaneous Acrylic Resins Contrast Media Pharmaceutical Science Nanoparticle 02 engineering and technology 010402 general chemistry 01 natural sciences Imaging phantom Mice chemistry.chemical_compound Nuclear magnetic resonance medicine Animals Particle Size Magnetite Nanoparticles Acrylic resin Acrylic acid medicine.diagnostic_test Phantoms Imaging Magnetic Phenomena Magnetic resonance imaging 021001 nanoscience & nanotechnology Embolization Therapeutic Magnetic Resonance Imaging Elasticity Microspheres 0104 chemical sciences chemistry Transmission electron microscopy visual_art visual_art.visual_art_medium Particle size 0210 nano-technology Superparamagnetism |
| Zdroj: | International Journal of Pharmaceutics. 511:831-839 |
| ISSN: | 0378-5173 |
| Popis: | To monitor the spatial distribution of embolic particles inside the target tissues during and after embolization, blank poly (acrylic acid) microspheres (PMs) were initially prepared by inverse suspension polymerization method and then loaded with superparamagnetic iron oxide (SPIO) nanoparticles by in situ precipitation method to obtain magnetic resonance imaging (MRI) detectable SPIO-loaded poly (acrylic acid) microspheres (SPMs). The loading of SPIO nanoparticles in SPMs was confirmed by vibrating sample magnetometer, transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy and infrared spectrum, respectively. The results showed that SPMs exhibited excellent superparamagnetism and the SPIO embedded in SPMs were proved to be inverse spinel magnetite. The content of SPIO loaded in wet SPMs of subgroups of 100-300, 300-500, 500-700 and 700-900μm was measured to be 11.84±0.07, 10.20±0.05, 9.98±0.00 and 8.79±0.01mg/ml, corresponding to the weight percentage in freeze-dried SPMs to be 18.07±0.28%, 18.54±0.13%, 18.66±0.01% and 18.50±0.07%, respectively. The SPMs were spherical in shape, had smooth surface, and were within the size range of clinical demands for embolization. The compression tests indicated that SPMs were more rigid than PMs and commercially used Embospheres (P |
| Databáze: | OpenAIRE |
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