Increased fibrinolysis and platelet activation in elderly patients undergoing coronary bypass surgery
| Autor: | Arne Åsberg, Lise Bjella, Hilde Pleym, Alexander Wahba, Roar Stenseth, Ola Dale, Vibeke Videm, Stian Lydersen |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Fibrinolysis Preoperative Care Medicine Humans Platelet activation Prospective Studies Coronary Artery Bypass Hemostatic function Blood Coagulation Aged Aged 80 and over Postoperative Care medicine.diagnostic_test business.industry Platelet Count Antithrombin Perioperative Middle Aged Platelet Activation Cardiac surgery Anesthesiology and Pain Medicine Bypass surgery Anesthesia Female business Partial thromboplastin time medicine.drug |
| Zdroj: | Anesthesia and analgesia. 102(3) |
| ISSN: | 1526-7598 |
| Popis: | Reexploration for hemorrhage after cardiac surgery is associated with increased morbidity and mortality. Elderly cardiac surgical patients have an increased risk of excessive bleeding and reexploration. In the present study we investigated the perioperative hemostatic function in elderly patients compared with younger patients undergoing coronary artery bypass grafting. Twenty-five elderly (75 yr and older) and 25 younger (younger than 60 yr) patients were included in the study. Blood samples for the analysis of platelet counts, international normalized ratio, activated partial thromboplastin time, fibrinogen, d-dimer, antithrombin, prothrombin fragment 1 + 2, thrombin-antithrombin complex, plasmin inhibitor, neutrophil-activating peptide 2, and platelet-monocyte complexes were drawn preoperatively, 30 min, and 3 h postoperatively and approximately 20 h postoperatively. Elderly patients had an increased activation of the hemostatic system. In particular, elderly patients showed a more pronounced increase in fibrinolysis and platelet activation postoperatively compared with younger patients. |
| Databáze: | OpenAIRE |
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