The common mouse protozoa Tritrichomonas muris alters mucosal T cell homeostasis and colitis susceptibility
| Autor: | Stephen E. Girardin, David Prescott, Catherine J. Streutker, Nichole K. Escalante, Paul Lemire, Arthur Mortha, Dana J. Philpott, Thierry Mallevaey, Mayra Cruz Tleugabulova |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
T cell T-Lymphocytes Immunology Priming (immunology) Microbiology 03 medical and health sciences Cecum Mice Immune system Immunity medicine Immunology and Allergy Animals Colitis Intestinal Mucosa Immunity Mucosal Research Articles Tritrichomonas Homeodomain Proteins Mice Knockout biology Brief Definitive Report medicine.disease biology.organism_classification 3. Good health 030104 developmental biology medicine.anatomical_structure Protozoa Disease Susceptibility |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | Escalante et al. show that a highly prevalent mouse intestinal protozoa, Tritrichomonas muris, was found to be a confounding factor in murine colitis. Mice infected with this parasite had elevated baseline levels of Th1 cytokines and developed exacerbated Th1-mediated disease. The mammalian gastrointestinal tract hosts a diverse community of microbes including bacteria, fungi, protozoa, helminths, and viruses. Through coevolution, mammals and these microbes have developed a symbiosis that is sustained through the host’s continuous sensing of microbial factors and the generation of a tolerant or pro-inflammatory response. While analyzing T cell–driven colitis in nonlittermate mouse strains, we serendipitously identified that a nongenetic transmissible factor dramatically increased disease susceptibility. We identified the protozoan Tritrichomonas muris as the disease-exacerbating element. Furthermore, experimental colonization with T. muris induced an elevated Th1 response in the cecum of naive wild-type mice and accelerated colitis in Rag1−/− mice after T cell transfer. Overall, we describe a novel cross-kingdom interaction within the murine gut that alters immune cell homeostasis and disease susceptibility. This example of unpredicted microbial priming of the immune response highlights the importance of studying trans-kingdom interactions and serves as a stark reminder of the importance of using littermate controls in all mouse research. |
| Databáze: | OpenAIRE |
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