Training program-induced skeletal muscle adaptations in two men with myotonic dystrophy type 1
| Autor: | Mélina Girardin, Marika Morin, Élise Duchesne, Anne-Marie Fortin, Marie-Pier Roussel, Jean Mathieu, Mario Leone, Cynthia Gagnon |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male Muscle Fibers Skeletal lcsh:Medicine Physiology Myotonic dystrophy General Biochemistry Genetics and Molecular Biology Muscle hypertrophy 03 medical and health sciences 0302 clinical medicine Endurance training Leukocytes Medicine Myocyte Humans Myotonic Dystrophy In patient 030212 general & internal medicine lcsh:Science (General) Muscle Skeletal lcsh:QH301-705.5 business.industry Myogenesis Myotonic dystrophy type 1 lcsh:R Skeletal muscle General Medicine Middle Aged medicine.disease Adaptation Physiological Research Note 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) Muscle plasticity Muscle growth Training program business lcsh:Q1-390 |
| Zdroj: | BMC Research Notes BMC Research Notes, Vol 12, Iss 1, Pp 1-6 (2019) |
| ISSN: | 1756-0500 |
| Popis: | Objective The purpose of this side product of another unpublished research project, was to address the effects of a training program on skeletal muscle adaptations of people with myotonic dystrophy type 1 (DM1), under a multifaceted perspective. The objective of this study was to look at training induced muscular adaptations by evaluating changes in muscle strength, myofiber cross-sectional area (CSA), proportion of myofiber types and with indirect markers of muscle growth [proportion of centrally nucleated fibers (CNF) and density of neutrophils and macrophages]. Two men with DM1 underwent a 12-week strength/endurance training program (18 sessions). Two muscle biopsies were obtained pre- and post-training program. Results Muscular adaptations occurred only in Patient 1, who attended 72% of the training sessions compared to 39% for Patient 2. These adaptations included increase in the CSA of type I and II myofibers and changes in their proportion. No changes were observed in the percentage of CNF, infiltration of neutrophils and macrophages and muscle strength. These results illustrate the capacity of skeletal muscle cells to undergo adaptations linked to muscle growth in DM1 patients. Also, these adaptations seem to be dependent on the attendance. Trial registration Clinicaltrials.gov NCT04001920 retrospectively registered on June 26th, 2019 |
| Databáze: | OpenAIRE |
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