Identification of Salivary Microorganisms and Metabolites Associated with Halitosis
| Autor: | Hong-Seok Son, Jae-Kwon Jo, Seong-Eun Park, Sun-Jae Kwon, Chang-Su Na, Kwang-Moon Cho, Seung-Ho Seo, Eun-Ju Kim, Young-Ho Moon, Hyunwoo Kim |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Saliva Endocrinology Diabetes and Metabolism microbiome medicine.disease_cause Microbiology Biochemistry Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Metabolomics halitosis Megasphaera Haemophilus Prevotella medicine putrescine Microbiome Molecular Biology Cadaverine biology cadaverine Streptococcus 030206 dentistry biology.organism_classification metabolomics QR1-502 030104 developmental biology chemistry |
| Zdroj: | Metabolites Volume 11 Issue 6 Metabolites, Vol 11, Iss 362, p 362 (2021) |
| ISSN: | 2218-1989 |
| DOI: | 10.3390/metabo11060362 |
| Popis: | Halitosis is mainly caused by the action of oral microbes. The purpose of this study was to investigate the differences in salivary microbes and metabolites between subjects with and without halitosis. Of the 52 participants, 22 were classified into the halitosis group by the volatile sulfur compound analysis on breath samples. The 16S rRNA gene amplicon sequencing and metabolomics approaches were used to investigate the difference in microbes and metabolites in saliva of the control and halitosis groups. The profiles of microbiota and metabolites were relatively different between the halitosis and control groups. The relative abundances of Prevotella, Alloprevotella, and Megasphaera were significantly higher in the halitosis group. In contrast, the relative abundances of Streptococcus, Rothia, and Haemophilus were considerably higher in the control group. The levels of 5-aminovaleric acid and n-acetylornithine were significantly higher in the halitosis group. The correlation between identified metabolites and microbiota reveals that Alloprevotella and Prevotella might be related to the cadaverine and putrescine pathways that cause halitosis. This study could provide insight into the mechanisms of halitosis. |
| Databáze: | OpenAIRE |
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