Effect of Acupuncture on Neuroplasticity of Stroke Patients with Motor Dysfunction: A Meta-Analysis of fMRI Studies
| Autor: | Yingjia He, Linqing Miao, Xing Chen, Xiaodong Liu, Lan Jiang, Guixing Xu, Tongtong Liu, Yihuai Zou, Rong Zhang, Jie Chen, Qiuyi Lv, Yuxin Pan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Acupuncture Therapy Neurosciences. Biological psychiatry. Neuropsychiatry Review Article Basal Ganglia law.invention 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Neuroimaging Randomized controlled trial law Neuroplasticity Acupuncture Humans Medicine Insular Cortex Stroke 030304 developmental biology 0303 health sciences Movement Disorders Neuronal Plasticity business.industry medicine.disease Data Accuracy Treatment Outcome Neurology Meta-analysis Neurology (clinical) Motor Deficit business Insula 030217 neurology & neurosurgery RC321-571 |
| Zdroj: | Neural Plasticity Neural Plasticity, Vol 2021 (2021) |
| ISSN: | 1687-5443 2090-5904 |
| DOI: | 10.1155/2021/8841720 |
| Popis: | Importance. Acupuncture is an effective treatment for stroke, especially in the aspect of motor deficit. Many brain imaging studies of acupuncture have found significant changes in brain function after acupuncture treatment in order to reveal its underlying mechanisms in regulating neural plasticity. However, no definite consensus has been reached. Objective. To analyze the pattern of intrinsic brain activity variability that is altered by acupuncture compared with conventional treatment in stroke patients with motor dysfunction, thus providing the mechanism of stroke treatment by acupuncture. Methods. Chinese and English articles published up to May 2020 were searched in the PubMed, Web of Science, EMBASE, and Cochrane Library databases, China National Knowledge Infrastructure, Chongqing VIP, and Wanfang Database. We only included randomized controlled trials (RCTs) using resting-state fMRI to observe the effect of acupuncture on stroke patients with motor dysfunction. R software was used to analyze the continuous variables, and Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) was used to perform an analysis of fMRI data. Findings. A total of 7 studies comprising 143 patients in the treatment group and 138 in the control group were included in the meta-analysis. The results suggest that acupuncture treatment helps the healing process of motor dysfunction in stroke patients and exhibits hyperactivation in the bilateral basal ganglia and insula and hypoactivation in motor-related areas (especially bilateral BA6 and left BA4). Conclusion. Acupuncture plays a role in promoting neuroplasticity in subcortical regions that are commonly affected by stroke and cortical motor areas that may compensate for motor deficits, which may provide a possible mechanism underlying the therapeutic effect of acupuncture. |
| Databáze: | OpenAIRE |
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