Antimalarial and cytotoxic drugs on COVID-19 and the cardiovascular burden: Literature review and lessons to be learned
| Autor: | Sherif Sultan, Yogesh Acharya |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
2019-20 coronavirus outbreak
hydroxychloroquine Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) review remdesivir Review Article Azithromycin 030204 cardiovascular system & hematology Antiviral Agents 03 medical and health sciences 0302 clinical medicine Chloroquine medicine Humans Cytotoxic T cell Radiology Nuclear Medicine and imaging 030212 general & internal medicine Alanine SARS-CoV-2 business.industry COVID-19 Hydroxychloroquine General Medicine Virology Adenosine Monophosphate COVID-19 Drug Treatment cardiovascular burden Cardiovascular Diseases Drug Therapy Combination Surgery Cardiology and Cardiovascular Medicine business Chemically-Induced Disorders medicine.drug |
| Zdroj: | Vascular |
| ISSN: | 1708-539X 1708-5381 |
| DOI: | 10.1177/1708538120941635 |
| Popis: | Background The world is witnessing an unprecedented crisis with Coronavirus disease 2019 (COVID-19). It is important to accurately analyze the available evidence to provide correct clinical guidance for optimal patient care. We aim to discuss current clinical evidence regarding chloroquine, hydroxychloroquine, azithromycin, remdesivir, and the cardiovascular burden of COVID-19. Methods A literature review was performed using PubMed and Google Scholar. Additional clinical trials were identified through the “TrialsTracker” project. Results We found conflicting evidence of chloroquine, hydroxychloroquine plus azithromycin, and remdesivir in COVID-19 despite promising early reports of in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2. Some of the current studies have demonstrated adverse drug reactions to chloroquine and hydroxychloroquine + azithromycin. Widespread systemic inflammation and procoagulant/hypercoagulable state, including thrombotic microangiopathy, endothelial dysfunction, bleeding disorder, and thrombosis are increasingly being witnessed in COVID-19. Evidence of cardiac injury and stroke is mostly reported in hospitalized patients; however, large specialized studies that focus on cardiac or neuropathology are lacking. Discussion There is no convincing clinical evidence of chloroquine, hydroxychloroquine with or without azithromycin, and remdesivir use in COVID-19. As evidence of systemic inflammation is rapidly unfolding, there is a dire need to maximize our resources to find the best possible solutions to the current crisis while conclusive evidence from clinical trials emerges. |
| Databáze: | OpenAIRE |
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