Transferability of Indirect Cost of Chronic Disease: A Systematic Review and Meta-Analysis

Autor: Hao Hu, Feng Xie, Shu-Chuen Li, Fei-Li Zhao
Rok vydání: 2013
Předmět:
Zdroj: PharmacoEconomics. 31:501-508
ISSN: 1179-2027
1170-7690
DOI: 10.1007/s40273-013-0053-6
Popis: Indirect cost is an important component in economic evaluations. The variation in the magnitude of indirect costs across studies and countries is substantial and affects the transferability of results across jurisdictions. This study explored the factors involved in the variation of reported indirect cost and investigated the feasibility of transferring indirect costs across settings. A systematic literature review was conducted to identify studies estimating indirect costs for four selected chronic diseases, namely, asthma (AS), diabetes (DI), rheumatoid arthritis (RA) and schizophrenia (SC). A multiple linear regression analysis was run to identify the factors that potentially explain the variation in reported indirect costs. Parametric (fixed- and random-effect models) and non-parametric (bootstrapping method) meta-analyses were applied to local gross domestic product (GDP)/capita-adjusted indirect costs for each disease. Results from the three different analytical methods were compared to ascertain the robustness of estimation. The systematic literature review identified 77 articles that reported indirect costs of AS (n = 18), DI (n = 20), RA (n = 25) and SC (n = 14) for literature synthesis. Substantial inter- and intra-disease variations among the indirect cost studies were observed with respect to geographic distribution, methodology and magnitude of cost estimation. Regression analysis showed that disease categories and local GDP/capita significantly (p
Databáze: OpenAIRE
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