A new series of natural antifungals that inhibit P450 lanosterol C-14 demethylase. I. Taxonomy, fermentation, isolation and structural elucidation
| Autor: | Yoshiko Itezono, Tatsuo Ohtsuka, Toru Okuda, Shoko Matsukuma, Nobuo Shimma, Kimihiro Watanabe, Kazuteru Yokose, Haruyoshi Shirai, Kotaki Hiromichi, Morio Fujiu, Noboru Nakayama, Takashi Sano |
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| Rok vydání: | 1992 |
| Předmět: |
Pharmacology
Antifungal Agents biology Antifungal antibiotic Stereochemistry Lanosterol Glycine Penicillium Fungi imperfecti Tetrahydropyran biology.organism_classification Sterol 14-Demethylase chemistry.chemical_compound chemistry Drug Discovery Fermentation biology.protein Demethylase Cytochrome P-450 Enzyme Inhibitors Oxidoreductases Pyrans |
| Zdroj: | The Journal of antibiotics. 45(2) |
| ISSN: | 0021-8820 |
| Popis: | A new series of antifungal antibiotics, Ro 09-1470 and its 6 congeners were isolated from the fermentation broth of Penicillium sp. NR6564. Their structures were determined as tetrahydropyran derivatives with an alkenyl side chain on the basis of their spectroscopic and physico-chemical properties. Among these compounds, Ro 09-1470 and Ro 09-1545 possessing a glycyl N-substituted glycyl ester residue had high antifungal activity. Ro 09-1469, one of the congeners, was found in the fermentation broth of several strains of Aspergillus sclerotiorum Huber. |
| Databáze: | OpenAIRE |
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