Genetic structure of Tibetan populations in Gansu revealed by forensic STR loci
| Autor: | Shujin Li, Bingying Xu, Lei Shang, Shao-Qing Wen, Qiajun Du, Liying Ma, Jiang Wang, Ying Huang, Chuan-Chao Wang, Xiaolan Tao, Hui Li, Hong-Dan Wang, Qiongying Deng, Li Jin, Hong-Bing Yao, Johannes Krause, Bin Cong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
education.field_of_study China Multidisciplinary Genotype Population Biology Tibet Article Gene flow Forensic identification 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Genetics Population Asian People Evolutionary biology Genetic structure Microsatellite Humans East Asia 030216 legal & forensic medicine education |
| Zdroj: | Scientific Reports |
| Popis: | The origin and diversification of Sino-Tibetan speaking populations have been long-standing hot debates. However, the limited genetic information of Tibetan populations keeps this topic far from clear. In the present study, we genotyped 15 forensic autosomal short tandem repeats (STRs) from 803 unrelated Tibetan individuals from Gansu Province (635 from Gannan and 168 from Tianzhu) in northwest China. We combined these data with published dataset to infer a detailed population affinities and genetic substructure of Sino-Tibetan populations. Our results revealed Tibetan populations in Gannan and Tianzhu are genetically very similar with Tibetans from other regions. The Tibetans in Tianzhu have received more genetic influence from surrounding lowland populations. The genetic structure of Sino-Tibetan populations was strongly correlated with linguistic affiliations. Although the among-population variances are relatively small, the genetic components for Tibetan, Lolo-Burmese, and Han Chinese were quite distinctive, especially for the Deng, Nu, and Derung of Lolo-Burmese. Han Chinese but not Tibetans are suggested to share substantial genetic component with southern natives, such as Tai-Kadai and Hmong-Mien speaking populations, and with other lowland East Asian populations, which implies there might be extensive gene flow between those lowland groups and Han Chinese after Han Chinese were separated from Tibetans. The dataset generated in present study is also valuable for forensic identification and paternity tests in China. |
| Databáze: | OpenAIRE |
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