Cardiac Resynchronization Therapy:. Gender Related Differences in Left Ventricular Reverse Remodeling
| Autor: | Paolo Pieragnoli, Alessio Lilli, Alessandro Paoletti Perini, Nicola Musilli, Maria Cristina Porciani, Giuseppe Ricciardi, Augusto Achilli, Stefano Del Pace, Luigi Padeletti, Massimo Sassara, Federico Turreni, Antonio Michelucci, Andrea Colella, S. Serge Barold |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Cardiac output medicine.medical_specialty medicine.medical_treatment Population Cardiac Output Low Cardiac resynchronization therapy Comorbidity Risk Assessment Ventricular Dysfunction Left Age Distribution Risk Factors Internal medicine Prevalence medicine Humans Sex Distribution education Ventricular remodeling Survival rate End-systolic volume Aged education.field_of_study Ejection fraction Ventricular Remodeling business.industry Cardiac Pacing Artificial General Medicine Middle Aged medicine.disease Survival Analysis Survival Rate Treatment Outcome Italy Heart failure Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Pacing and Clinical Electrophysiology. 30:1349-1355 |
| ISSN: | 1540-8159 0147-8389 |
| Popis: | Aim:Gender related differences in epidemiology, treatment, and prognosis of heart failure (HF) have been reported. We examined the sex influence in patients treated with cardiac resynchronization therapy (CRT). Methods and Results:Out of 334 consecutive HF patients (19.7% women) who underwent CRT, 195 patients reached clinical and echocardiographic evaluation at six and 12 months and were selected for analysis. A reduction in left ventricular (LV) end-diastolic volume/m2 (EDVi) and end systolic volume/m2 (ESVi) was evident in the overall population at six months (P < 0.001) and from six to 12 months (P < 0.001). Compared to men, women showed significantly greater changes in LV volumes at mid (P < 0.05) and long-term (P < 0.001) follow-up and a significantly higher LV ejection fraction (EF) (40.8 ± 12.3 vs 34.1 ± 10.1, P < 0.01) at one year. Multiple regression analysis, including several demographic and clinical parameters, revealed that female gender is independently associated with greater reduction in LV ESVi. At the 12-month follow-up, the proportion of responders (defined in terms of ESV reduction by at least 10%) was higher in women than in men (76.1% vs 59.3%, P < 0.05). Conclusions:CRT induced a gender specific LV remodeling response. |
| Databáze: | OpenAIRE |
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