Arthralgia among women taking aromatase inhibitors: is there a shared inflammatory mechanism with co-morbid fatigue and insomnia?
| Autor: | Jinbo Chen, Michael Kalos, Joshua Bauml, Angela DeMichele, Susan Q. Li, Jun J. Mao, Jean D. Boyer, Lu Chen |
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| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Antineoplastic Agents Hormonal Cross-sectional study Breast Neoplasms Comorbidity 03 medical and health sciences 0302 clinical medicine Breast cancer Sleep Initiation and Maintenance Disorders Internal medicine Prevalence medicine Humans Brief Pain Inventory Fatigue Aged Neoplasm Staging 030304 developmental biology 2. Zero hunger Gynecology Medicine(all) 0303 health sciences biology Aromatase Inhibitors business.industry C-reactive protein Middle Aged medicine.disease Arthralgia 3. Good health Discontinuation C-Reactive Protein Cross-Sectional Studies 030220 oncology & carcinogenesis biology.protein Biomarker (medicine) Female Inflammation Mediators business Body mass index Biomarkers Research Article |
| Zdroj: | Breast Cancer Research : BCR |
| ISSN: | 1465-542X |
| DOI: | 10.1186/s13058-015-0599-7 |
| Popis: | Introduction Arthralgia is a common toxicity among women taking aromatase inhibitors (AIs) and can lead to premature discontinuation of therapy. We evaluated the association between arthralgia, co-morbid fatigue and/or insomnia, and inflammatory biomarkers among women taking AIs. Methods Women taking AIs for early-stage breast cancer completed a modified version of the Brief Pain Inventory, the Brief Fatigue Inventory, and the Insomnia Severity Index and provided blood samples for simultaneous assessment of 34 inflammatory biomarkers with a Luminex kit. Two-sided t tests were used to compare inflammatory biomarker concentrations for patients with or without moderate to severe arthralgia. Multivariate linear regression analyses were performed to evaluate the relationship between comorbid arthralgia, fatigue, and insomnia with identified biomarker concentrations. Results Among 203 participants, the severity of arthralgia, fatigue, and insomnia were significantly correlated with each other (p |
| Databáze: | OpenAIRE |
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